When a couple fails to get pregnant or has an unsuccessful pregnancy, a number of tests performed on both partners is recommended. One of the basic tests in analysis of the male partner involves performing a seminogram or spermiogram that provides us with an initial indication of semen quality. This information can be supplemented with a sperm DNA fragmentation analysis, should this be considered necessary.
The DNA fragmentation test is a technique that supplements a study of the male factor in certain cases. […]
Cryptorchidism, from the Greek words kriptos (hidden) and orquis (testicle), is the failure of one or both testes to descend to the scrotum. It is estimated that between 2 and 5% of newborn boys have this abnormality although the figure rises to 30% when premature boys are taken into account. In many cases, the issue resolves itself naturally and, as a result, at one year of age, only 1% of boys have the condition. […]
Turner syndrome is a chromosomal condition caused by partial or total loss of one of the X chromosomes.
All human beings have 23 pairs of chromosomes and this is what is known as the karyotype. It is where all genetic information is stored. In other words, it is what determines our external appearance, our personal physical characteristics, how our organs work, whether or not we will have certain illnesses and so on. There are 22 pairs of numerical chromosomes ranging from 1 to 22 and one pair of sex chromosomes: X and Y. Women have two X chromosomes – one from their father and one from their mother. Men have one X chromosome – from their mother – and one Y chromosome – from their father. If, when a female embryo is generated, incorrect division leading to total or partial loss of the X chromosome takes place, this generates an abnormal karyotype that is characteristic of women with Turner syndrome. The syndrome, by definition, does not occur in males because they only have one X chromosome and cannot live unless this chromosome is present. […]
Spontaneous abortion is defined as an unexpected pregnancy loss before the foetus is viable. In other words, before week 22 of pregnancy and under 500g in weight. The frequency rate of spontaneous abortion is estimated to be between 15 and 20% amongst the general population and it is the most common of all complications during pregnancy.
A small percentage (between 2 and 5%) of cases are recurrent and this is what is known as recurrent pregnancy loss (RPL). […]
The advantages of comprehensive chromosome screening (PGS/PGT-A/CCS) in women of an advanced maternal age
Women currently seek guidance on reproduction at a much older age than they did some years ago. As a result, amongst the women who undergo fertility treatment, there is a significant group of women of an advanced age and their prognosis is poorer. This is a huge challenge for reproduction specialists. […]
Human immunodeficiency virus (HIV) is a retrovirus and, during its most advanced stage of infection, it leads to acquired immunodeficiency syndrome (AIDS). Whilst there is currently no cure for HIV/AIDS, antiretroviral treatments do exist that stop the symptoms from developing or delay them until later. As such, we come across increasing numbers of couples of childbearing age who wish to have children and in which one of the partners is a carrier of the virus. […]
A patient can be classified as having poor response when the number of oocytes obtained during a cycle of in vitro fertilisation is under what was expected. The criteria generally used to label a patient as a poor responder is when 3 or fewer oocytes are retrieved and she has incredibly low ovarian reserve markers (fundamentally, AMH and AFC). […]
Assisted hatching is a laboratory technique that consists of making a small hole in the zona pellucida, the membrane surrounding the embryo, in order to make it easier for the embryo to hatch out (something that naturally needs to happen) and implant in the uterus. […]
Sexually transmitted disease (STDs) are infections that are transmitted, on the whole, during unprotected sexual intercourse. However, they can also be transferred from mother to child during pregnancy.
Fragile X syndrome is one of the most common causes of hereditary intellectual disability.
The gene responsible for the disease is known as FMR1 and it is found in the X sex chromosome. As a result, both the transmission and the severity of the disorder varies in each sex. As a general rule, men are said to suffer from it whilst women are said to transmit it.
There is a repeat region in the FMR1 gene (expansion) and its size determines whether or not the individual has the disorder or not, as indicated below. […]