Poor Ovarian Response: progress in genetics

Ovarian stimulation is key in results obtained as a results of assisted reproduction techniques. Daily clinical practice shows us that ovarian response can vary substantially from one woman to another. With this in mind, we can diagnose a patient as a poor responder when three eggs or less are obtained.
This situation affects more and more women every day. They require specialised healthcare and personalised protocols and, in response to this need, Instituto Bernabeu has a Poor Ovarian Response Unit that deals with multidisciplinary diagnosis and treatment.
For patients under this category, obtaining one or more eggs can mean the difference between failure and pregnancy and this makes any steps taken to increase the number of available eggs absolutely essential. […]

Recurrent pregnancy loss: an issue that does have a solution

Clearly one of the most difficult situations a couple trying for children may have to face is pregnancy loss. Suffering is even greater when, prior to this, the couple has gone through fertility treatment such as in vitro fertilisation, insemination or egg donation.
Pregnancy loss is not always the result of an illness or underlying abnormality. It can be the response nature provides in order to block the development of an abnormal embryo. In fact, when the tissue from the pregnancy loss is examined, a large number of chromosomal abnormalities can be detected. […]

State of the art technology in preimplantation embryo diagnosis: Array-CGH

Preimplantation Genetic Diagnosis (PGD) is the study of chromosomal and genetic abnormalities in embryos before they are transferred to the mother’s uterus by an In Vitro Fertilisation (IVF) technique. It seeks to ensure healthy offspring and stop transmission of a given disease. […]

What does embryo biopsy involve?

Preimplantation Genetic Diagnosis (PGD) is a tool designed to “get to know” the embryos genetically before they are transferred into the mother’s uterus. Thanks to this technique, we can study their chromosome count and find out if they are carriers of a hereditary disease. This information helps us to select the embryos that will produce healthy babies. Yet, how can we find that information?
Today, the only way to find genetic information about embryos is by performing an embryo biopsy. What does embryo biopsy involve?
To explain the biopsy procedure we should keep in mind that our point of departure is EMBRYOS. Embryos are retrieved after performing an assisted reproduction cycle, preferably by Intracytoplasmic Sperm Injection (ICSI), and their development is assessed during the culture period until day 3 or day 5. […]

Usefulness of the Karyotype

The karyotype is the number of chromosomes in metaphase that we have. Chromosome count and therefore karyotype are characteristic to each species. Human beings have 46 chromosomes (23 pairs) in the nucleus of each cell in their body. These 23 pairs are organised into 22 pairs termed autosomes and one pair of sex chromosomes (X and Y) that differentiates both sexes (men XY and women XX). […]

Why does Comprehensive Chromosome Screening (CCS) by array-CGH reduce miscarriage rates?

Miscarriage rates in the general population with no fertility problems range around 15-20%. In other words, one out of every five couples who achieve pregnancy suffers a spontaneous miscarriage, and 5% of these couples suffer it more than once. Even when pregnancy is achieved with the help of assisted reproduction techniques, miscarriage rates do not vary. For this reason, it is important when couples come to our clinic seeking reproductive counselling to perform comprehensive testing and design an adequate protocol for their case to secure the best result, which is a healthy baby at home, minimising the chances of miscarriage. In order to do that, one should know that miscarriages and pregnancy losses are caused by different reasons (uterine problems, immunological problems, and so on), and yet in half the cases there are chromosomal abnormalities in the embryo that prevent pregnancies to progress, hence causing miscarriages. Normal embryos have two copies of each chromosome, one inherited from the father and the other from the mother, and the chromosomal anomalies they may suffer involve a change in the number of copies, producing an imbalance in their genetic load which might block embryo development. […]

A revolution in genetics: next generation DNA sequencing

In the year 2000, human sequencing was achieved following 10 years of scientific work and now, thanks to next generation DNA sequencing, we are able to get to know a human genome in the space of just one week. It is still not possible, however, to access 100% of the genetic information contained within an embryo, the true origin of human life. But scientific progress is unstoppable and with this new technique a new range of promising options for genetics, for fertility and for life have opened up.
According to researchers, the possibilities which DNA sequencing offers are revolutionary and huge. Despite being at a very initial stage in which only the tip of the next generation sequencing iceberg has been uncovered, the number of uses is so varied that determining how to manage everything this technique implies will, in fact, be the future’s biggest challenge.
For the time being, thanks to human sequencing, nowadays “there is greater power of analysis and this facilitates many things and very significant possibilities”, explains the scientist and molecular biology and genetics investigator at Instituto Bernabeu, José Antonio Ortiz. The new technique, which can only be carried out in leading international clinics such as IB, “has revolutionised genetics. Genetic studies are now much quicker.’ […]

By |5 de February de 2016|Fertility, Genetics, Gynaecology, News, Reproductive biology|0 Comments

Instituto Bernabeu strengthens is position as a European reference in matters of R&D at the Annual Congress of the British Fertility Society.

The British Fertility Society (BSF) Annual Congress, one of Europe’s leading fertility and assisted reproduction events, was held on 7th and 8th January in Newcastle (UK). Its scientific committee accepted a total of 11 pieces of research work prepared by Instituto Bernabeu (Alicante) as part of the group’s main lines of R&D. These include poor ovarian response – a pathology which is largely associated with attempts to fall pregnant later on in life –  embryo implantation failure and the impact of genetics on reproduction issues. […]

Assisted Reproduction in women who do not have a male partner

In modern society, the increasing demand for assisted reproduction techniques from single women and same-sex couples has become a reality. From the perspective of reproduction, women only need to receive the male gamete (sperm). For years, these couples have solved the problem in ways that have not always been medically or legally safe and have had to face the possibility of infectious diseases and paternity suits.
Today, these inconveniencies are solved in assisted reproduction centres, where procedures that meet their demands and offer them a solid and safe foundation are regularly performed.
Thanks to Assisted Reproduction Techniques (ART), Reproductive Medicine enables us to distinguish the fact of reproduction from the act of intercourse between two people. Several options for motherhood are offered to both single women and […]

The Rafael Bernabeu Foundation and its social welfare calling

The Rafael Bernabeu Foundation, the social welfare foundation at Instituto Bernabeu, has been working towards helping to improve health, well-being and financial conditions in society since 2007. Support programmes for patients with financial difficulties, scholarships and long-term support for various NGOs and academic and medical institutions are just some examples of the work which is carried out “as part of our commitment to the people of Alicante.” To the company, “social responsibility is a must.”

The foundation was set up at almost the same time as Instituto Bernabeu in Alicante. Whilst work went on in the reproduction and fertility clinic, the needs of the local population surrounding the medical group as it grew and became more consolidated became clear. It was the company’s closest reality, its closest community, the people who could potentially one day walk past one of the groups newest branches. IB began donating part of its financial resources and this increased as the institution grew. Along with the company’s growth and strength came the decision to provide this giving spirit, which had been active for many years, with a more formal structure. The Rafael Bernabeu Foundation was born in the cold month of January 2007 with the aim of providing different causes and adverse circumstances with warmth and solutions.

“Our patients and everyone in the IB team are participants in this support aimed at the very same society which has enabled us to grow and to which we wish to return the favour,” says the Rafael Bernabeu Foundation. Since it was set up, its work, donations and activities have grown and centred around three core areas: health, training and financial support for NGOs. […]

By |4 de January de 2016|Fertility, Genetics, Gynaecology, News, Pregnancy|0 Comments