Archive for the 'Genetics' category

Genetic incompatibility between the couple, does it exist?

Sep 29 2014 Published by under Fertility, Genetics, News

01It is estimated that about 20% of reproductive problems are genetic or chromosomal type. That is why today genetic testing is an essential part of the fertility study in couples who come to our clinic looking for descendants.

For the diagnosis of fertility problems there is a set of genetic studies very useful in the assistance of couples with reproductive desire. Tests such as the karyotype in both partners, microdeletion of the Y chromosome in the male or the molecular study of fragile X syndrome in women are usually required tests to determine a possible genetic basis of fertility problems in couples. Continue Reading »

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Selection of egg donors at Instituto Bernabeu

01Currently, oocyte donation is probably the most demanded technique in fertility centers, mainly due to the increase of maternal age. Voluntary participation of donors is essential, but donors must be evaluated carefully in order to avoid unsatisfactory results (do not forget that the ultimate goal is the birth of a healthy child without prejudice to the donor or the recipient couple).
In a recent study carried out in our center and presented at the Congress of the British Fertility Society, the leading causes of rejection in our program were evaluated in 560 potential egg donors. Continue Reading »

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Can we avoid the Genetic Ammiocentesis?

01 Genetic Amniocentesis is a prenatal diagnostic technique aimed at obtaining fetal karyotype. The karyotype is the number of chromosomes that are endowed with all people. Normal people we have 46 chromosomes distributed in 23 pairs (22 pairs of chromosomes called autosomes and 1 pair of sex chromosomes, XX or XY, which determine the sex of the fetus). Down syndrome or trisomy 21 is the most common chromosomal abnormality in new born infants; in this case, the individual has 47 chromosomes, and the alteration is that there are 3 21 chromosomes rather than two. Continue Reading »

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Why not all embryos obtain from a cycle of in vitro fertilization are suitable for freezing?

01 Today, in In Vitro fertilization treatments, it is not extraordinary to find ourselves on the day of embryo transfer with a high number of good quality embryos. For a fresh transfer we shall be electing the embryo or embryos that morphologically and kinetically demonstrate greater development and ‘the other’ good quality ones can be cryopreserved. Continue Reading »

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Criteria for embryo classification

01From fertilization and until the embryo transfer takes place in the womb, embryos follow a development that is valued by embryologists daily. Those embryos that have kept a correct evolution and are in better condition are selected to be transferred. Continue Reading »

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Difference between identical and fraternal twins

Apr 17 2014 Published by under Genetics, Gynaecology, News, Pregnancy

01Before establishing the biological origin differences between identical and fraternal twins, let’s make a quick note on the etymology of both words.

Etymologically both terms have the same origin (Latin gemellicium) and were used interchangeably to refer to children born in the same delivery. The only difference was the use of the term fraternal twin in the popular speech twin and identical twin in the cultivated speech. However, the semantic evolution of both words has been accompanied by the numerous advances in the field of genetics and knowledge of the development of the human embryo. In fact, since they differ in the latest edition of the dictionary of the RAE: Continue Reading »

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What is a Chemical Pregnancy?

01 There are times when we give patients the results of  in vitro fertilization, we tell them that the test is positive but that it is not good news, and that the chances that it evolves into an ongoing pregnancy are slim. It is a very difficult situation, emotionally, since it is very hard for patients to understand what has happened. If it really is positive, then why isn’t that good news? If it’s not good news, then why do I still have to take medication?

Most of these cases will show a negative result some days later, and it is considered a chemical pregnancy. What has happened is that there was implantation of the embryo (if not the  bHCG could not have come back positive) and the embryo stopped developing some days later. This is simply a very early miscarriage, so early that it cannot be confirmed via ultrasound, and is resolved without any medication or D&C.

This situation occurs in around 10% of IVF cycles. This means that around 1 in 10 embryo transfers, the pregnancy test is positive but the pregnancy will never be seen on an ultrasound. This is clearly linked to the  bHCG levels taken 8-10 days after embryo transfer, but must be confirmed a few days later with another test, as we explained previously.

These “chemical pregnancies” are not only in assisted reproduction, but also occur naturally in spontaneous pregnancies. The majority of them are undiagnosed, because women confuse them with delays in their period. However with new pregnancy tests, which are getting more sensitive, women more frequently are seeing unclear or positive results then are then negative a few days later. This should be seen as a natural part of reproduction: just as some embryos are unable to implant, others that do are not able to continue their development, and never seen on an ultrasound.

Patients are obviously full of doubts when this situation arises: what consequences does this have in the future? Is this an obstacle in trying to obtain a pregnancy? Does it lessen the chances in a future attempt?

02The answers we can give based on scientific evidence are quite positive. Couple who have a positive result have a better prognosis in future attempts. This has been proven in a number of publications  and should be explained to patients so that it is taken into account when making a decision.

Even though it does not mean anything negative in the reproductive future of a couple, many chemical pregnancies cause a sense of “loss” that adds to the emotional burden  already present for people with fertility problems. This is why we should always be present for any concerns that these patients may have, and give them all the necessary information that they need to overcome the situation and continue to try and reach their goal.

Dr. Joaquín Llácer, gynecologist for Instituto Bernabeu.

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More information on our website: www.institutobernabeu.com/en/ or www.ibbiotech.com

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Genetic approach to embryo implantation failure and repeated miscarriage

Couples that don’t achieve pregnancy after in vitro fertilization treatments and those who lose their pregnancy in early stages require a multidisciplinary approach in order to diagnose and treat their reproductive problem.

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From a genetic point of view, these patients are more likely to produce embryos with chromosomal abnormalities. To improve these couples’ pregnancy rates, the preimplantational genetic diagnosis (PGD) can be applied. In these cases, the goal is to select the embryos with the highest capacity of resulting in an ongoing pregnancy thanks to the fact that the PGD allows us to identify the number of chromosomes in the embryo. Only embryos with the correct number of chromosomes can lead to a healthy child, others will arrest in their development or will lead to a miscarriage. Continue Reading »

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Using Magnetic Fields to Select Healthy Sperm: MACS (Magnetic Activated Cell Sorting)

MACS Instituto BernabeuIt is well known that having the best possible sperm quality is important to the success of assisted reproduction techniques. To achieve this, the lab has to improve sperm quality based on its motility and morphology, selecting the sperm that is considered to be the best.

However in every ejaculate sperm with abnormal membranes are found, which are programmed to “die”. This process is called apoptosis, or programmed cell death.   Approximately 20% of sperm in subfertile patients are  thought to be in the process of “celular death”. Continue Reading »

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Instituto Bernabeu Shared Risk Program: serious commitment to the result

“WE’RE NOT TALKING ABOUT STATISTICS, WE ENSURE YOUR PREGNANCY.”

Instituto Bernabeu has always been loyal to its patient care philosophy, and is even more so now in these current hard times, by planning and implementing new projects and services aimed at helping couples achieve their dream of parenthood.

We want to share your efforts and risk by promising to back up every activity with the latest equipment, innovative techniques and cutting-edge technology alongside our entire team’s professionalism, experience, warmth and dedication. Continue Reading »

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