When in vitro fertilisation treatment commences, one of the aims is to try and achieve an appropriate number of good quality embryos in the laboratory so that the best ones can be selected and transferred. Whilst the Spanish law on assisted reproduction (Law 14/2006) permits transfer of a maximum of 3 embryos per cycle, progress in techniques has meant that […]
Egg donation has become an option for women who, for whatever reason, can no longer use their own ova. For example, due to poor ovarian reserve, poor oocyte quality and premature menopause.
The process is widely used in Spain. As well as exceeding organ
donations and transplants in number, we also have the largest number of egg
donors in Europe.
Personalising courses of treatment is undoubtedly currently the
most important area of change in the field of medicine. A specific strategy should be designed
depending on each patient’s individual characteristics.
One of the key areas for developing personalised medical healthcare is the use of pharmacogenetics. A patient needs different doses or types of pharmaceutical drugs depending on certain genetic variations. […]
Turner syndrome is a chromosomal condition caused by partial or total loss of one of the X chromosomes.
All human beings have 23 pairs of chromosomes and this is what is known as the karyotype. It is where all genetic information is stored. In other words, it is what determines our external appearance, our personal physical characteristics, how our organs work, whether or not we will have certain illnesses and so on. There are 22 pairs of numerical chromosomes ranging from 1 to 22 and one pair of sex chromosomes: X and Y. Women have two X chromosomes – one from their father and one from their mother. Men have one X chromosome – from their mother – and one Y chromosome – from their father. If, when a female embryo is generated, incorrect division leading to total or partial loss of the X chromosome takes place, this generates an abnormal karyotype that is characteristic of women with Turner syndrome. The syndrome, by definition, does not occur in males because they only have one X chromosome and cannot live unless this chromosome is present. […]
Oocyte quality is one of the most important of the factors that have an impact on fertility in women. Optimum oocyte quality generally gives rise to embryos with an increased ability to implant in the uterus. […]
Fragile X syndrome is one of the most common causes of hereditary intellectual disability.
The gene responsible for the disease is known as FMR1 and it is found in the X sex chromosome. As a result, both the transmission and the severity of the disorder varies in each sex. As a general rule, men are said to suffer from it whilst women are said to transmit it.
There is a repeat region in the FMR1 gene (expansion) and its size determines whether or not the individual has the disorder or not, as indicated below. […]
These are just some of the questions that couples might ask at an important time during their treatment, just before embryo transfer.
In all cases of fertility treatment involving the in vitro fertilisation (IVF) laboratory, it is essential that all couples are given extensive, detailed and personalised information. This means talking about the embryo fertilisation and development processes.
When only a few fertilised oocytes are available as a result of poor ovarian reserve, transfer is carried out on day 2 or 3 of development in around 60% of cases because at this stage we can clearly select the embryos that are suitable for transfer. In around half of these cases it is not possible to cryopreserve embryos for future attempts. […]
If you’re thinking about becoming a mother using donated eggs, here are eight questions and answers for you
As is only to be expected, women have a number of doubts when they first take the important decision to become a mother using an egg donated by another women. The first reaction is one of shock when a woman finds out that she will need to rely on egg donation. Once they have had time to come to terms with the situation, many women take it on board naturally and accept the option that will allow them to give birth to their child. For others, however, the process takes longer and it needs to be thought through before it can be accepted or, in some cases, rejected.
Women go through what is known as genetic mourning during the process when they become aware of the fact that the baby will not have their genes. According to the experts at Instituto Bernabeu, accepting this situation from the outset is the best way forward if patients are to avoid turning the doubts and questions that come up along the way into a concern or even an obsession for the future mother. […]
Should I tell my children they were born as a result of in vitro fertilisation (IVF) or egg donation?
One of the questions that couples frequently ask me in their appointments is if they should tell their child that they were the result of IVF or egg donation? How will the child react when told?
The answer needs to be thought through and only you will find the one that’s right for you. Your personality is based on a number of factors such as principles, education, opinions (prejudices), beliefs and experiences that shape your thoughts and, as such, the way you feel and act. In order to get a clear answer, I suggest you put those opinions aside and take all the time you need. Set your irrational thoughts aside and the answer will come to you. There are couples who do not know what they will do until their child is born. However, once you’ve decided, don’t doubt your choice. Accept the consequences and be consistent. Whatever you decide to do, be sure that it makes you happy because being happy is a decision. […]
Follicular puncture, or ovarian puncture, is one of the fundamental stages of in vitro fertilisation (IVF). It consists of surgery in order to retrieve eggs from inside follicles in the ovary. Excellent patient satisfaction and well-being when using these techniques reduce the emotional stress that they generate.
Huge progress has been made in the field of assisted reproduction and these steps forward will always be thought of as historical milestones in medicine. Comfort and safety are some of the most significant improvements that have been made. During the early days of IVF, eggs were retrieved by means of ovarian puncture under general anaesthetic delivered by inhalation. This technique was relatively cumbersome and egg retrieval results were low in comparison with the technique used nowadays. Patients were required to stay overnight at the clinic. […]