Reproductive biology

Absent uterus or Mayer-Rokitansky-Küster-Hauser syndrome: what can I do?

Mayer-Rokitansky-Küster-Hauser syndrome – or simply MRKH syndrome – is a congenital disorder (birth defect), the main characteristic of which is that the women who suffer from it do not have a uterus.

The cause of this infrequent condition (1 in 5,000 female births) is an abnormality during development of the internal genitalia during the embryo/foetus stage. As well as an […]

2019-06-05T11:41:18+02:007 de June de 2019|1 Comment

Is the EmbryoGlue® culture medium that is used during embryo development efficient?

Culture mediums used during embryo development in in vitro fertilisation (IVF) laboratories are crucial to the exit of assisted reproduction treatment of any kind. Culture mediums have the mission of reproducing the physiological conditions inside the female reproductive system as closely as possible, embracing fertilisation up until embryo implantation in the endometrium.

In order for implantation to take place during […]

2019-03-29T09:40:39+02:0029 de March de 2019|0 Comments

What happens to excess embryos following assisted reproduction treatment?

When in vitro fertilisation treatment commences, one of the aims is to try and achieve an appropriate number of good quality embryos in the laboratory so that the best ones can be selected and transferred. Whilst the Spanish law on assisted reproduction (Law 14/2006) permits transfer of a maximum of 3 embryos per cycle, progress in techniques has meant that […]

2019-03-08T10:01:34+02:008 de March de 2019|0 Comments

Can patients manage embryo and gamete transportation?

Whilst it is not part of the day-to-day routine at reproductive
medicine clinics, it is now increasingly common to have to transport biological
samples (oocytes, semen or embryos) from one clinic to another and even from
one country to another.

There can be several reasons for this such as the following:

– The
couple wishes to continue their treatment in a […]

2019-02-08T10:17:41+02:008 de February de 2019|0 Comments

Exhaustive sperm donor selection and exclusion criteria

Nowadays, many couples have to turn to gamete donation in order
to make their dream of becoming parents come true. In cases such as these, the
couple tends to have common and understandable doubts about reproduction
treatment clinics’ processes for accepting gamete donors onto their banks.

Let us use this forum to explain the semen donor selection process at Instituto Bernabeu […]

2019-02-01T12:01:16+02:001 de February de 2019|0 Comments

Progress in treatment for patients with poor ovarian response

Personalising courses of treatment is undoubtedly currently the
most important area of change in the field of medicine. A specific strategy should be designed
depending on each patient’s individual characteristics.

One of the key areas for developing personalised medical healthcare is the use of pharmacogenetics. A patient needs different doses or types of pharmaceutical drugs depending on certain genetic variations. […]

2019-01-23T10:37:32+02:0025 de January de 2019|0 Comments

AIDS. Assisted reproduction is the best option

The risk of contracting HIV during unprotected sexual intercourse is estimated to be between 0.5 and 1%. For serodiscordant couples (one partner is a carrier), trying for a child naturally can entail an elevated risk of transmission. In cases such as these, assisted reproduction techniques are an excellent choice for getting pregnant without the risk […]

2019-01-11T10:57:28+02:0011 de January de 2019|0 Comments

Embryonic development: the embryo on day 1 (D1)

When an oocyte is in an optimum state of maturation, ovulation takes place. This is known as day 0 of development (D0) and fertilisation by a competent spermatozoon must take place during this period.

When the oocyte is fertilised, it is then known as a zygote and
we are now on D1 of development. Certain characteristics and essential
structures need […]

2019-01-04T09:51:56+02:004 de January de 2019|0 Comments

Embryo fragmentation

Embryo fragmentation is a phenomenon that takes place in most embryos and its origin is not entirely clear. Some studies would seem to suggest that the fragments come from cell remains that have no nucleus or that they are the result of the decomposition of one or more cells from the embryo itself. The oocyte plays the most important role in fragmentation. Poor oocyte quality can lead to embryos that are highly fragmented. Embryo quality is determined by several characteristics such as the number of cells, their size or if the cell interior has an abnormality of any kind such as granularity or vacuolisation. However, one of the factors that has most impact on embryo quality is the extent of fragmentation. Based on the amount, in percentage, of space that it occupies, fragmentation is categorised into 4 types or degrees. […]

2018-12-17T11:07:30+02:0021 de December de 2018|0 Comments

The importance of embryo nutrition in achieving a successful cycle of in vitro fertilisation (IVF): metabolomics

One of the main limitations of assisted reproduction techniques are its embryo implantation failure rates. The implantation rate is the embryo’s ability to implant in the mother’s uterus. In other words, not all embryos are able to give rise to a pregnancy. Some have a greater chance of doing so than others. If it were possible to select embryos with the greatest ability to implant, it would be possible to improve assisted reproduction technique success rates. […]

2018-12-14T10:23:05+02:0014 de December de 2018|0 Comments
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