Poor Ovarian Response Unit

Pharmacogenetics for the treatment of low ovarian response

The application of pharmacogenetics to ovarian stimulation will specially benefit women with low ovarian response.

What is pharmacogenetics?

There are many variables
that can modify the effects of the drugs on each person and, among them, there
are genetic factors. In recent years it became evident that the genetic profile
of patients can explain the differences in response to drugs […]

2020-09-14T10:54:37+02:0014 de September de 2020|0 Comments

Premature Ovarian Failure, Can I be a mother? Causes, symptoms, diagnosis, treatment and prevention

A woman’s ovarian reserve is limited in time and decreasing until it is definitively exhausted when menopause takes place around the age of 45-50. However, in 1% of women a premature depletion of the eggs occurs which leads to the total or partial cessation of ovarian function before the age of 40. We call this […]

2020-08-17T17:26:53+02:0013 de August de 2020|0 Comments

Double stimulation: is it possible to recover more oocytes in patients with low ovarian reserve?

The double ovarian stimulation or DuoStim is an ovarian stimulation protocol in which two stimulations and two oocyte collections are performed during a single menstrual cycle (approximately 28 days). It consists of first stimulation in the follicular phase and a second stimulation in the luteal phase.

In what cases is DuoStim indicated?

The patients who benefit most […]

2020-08-25T09:41:58+02:0027 de July de 2020|0 Comments

Progress in treatment for patients with poor ovarian response

Personalising courses of treatment is undoubtedly currently the most important area of change in the field of medicine. A specific strategy should be designed depending on each patient’s individual characteristics.

Pharmacogenetics: a personalized medicine and tailored drug prescription

One of the key areas for developing personalised medical healthcare is the use of pharmacogenetics. A patient needs different doses or […]

2020-08-17T17:19:29+02:0025 de July de 2020|0 Comments

Is ovary size important?

As is the case with all the organs in our bodies, over our lifetime, ovaries go through changes that affect not only their size but also how they perform. The ovaries are situated between the uterus and the fallopian tubes. They are essential to reproduction and, therefore, to the survival of the human race.

The ovaries begin to develop when female embryos are around 8 weeks old and during pregnancy they undergo a number of changes that prepare them for their role in reproduction when a woman is in her childbearing years.

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2020-08-18T09:52:44+02:0016 de July de 2020|0 Comments

Poor Ovarian Response: progress in genetics

Ovarian stimulation is key in results obtained as a results of assisted reproduction techniques. Daily clinical practice shows us that ovarian response can vary substantially from one woman to another. With this in mind, we can diagnose a patient as a poor responder when three eggs or less are obtained.

This situation affects more and more women every day. They require specialised healthcare and personalised protocols and, in response to this need, Instituto Bernabeu has a Poor Ovarian Response Unit that deals with multidisciplinary diagnosis and treatment.

For patients under this category, obtaining one or more eggs can mean the difference between failure and pregnancy and this makes any steps taken to increase the number of available eggs absolutely essential.

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2020-08-18T10:43:39+02:0015 de July de 2020|0 Comments

Accumulation of oocytes in patients with a low response

The number of oocytes retrieved is a key prognostic factor in In Vitro Fertilisation (IVF) treatments. Chances are greater the greater the number of retrieved oocytes is, until the moment when 6 to 8 oocytes have already been retrieved.

For this reason, care of patients with a Low Response should be especially thorough, both as regards the chosen protocol for ovarian stimulation and the processes of oocyte retrieval and management at the laboratory. In these cases, retrieving an extra oocyte may considerably increase the chances of success.

While many of these patients benefit from the implementation of specific stimulation protocols and the use of adjuvant therapies, some of them will be refractive and will yield a very poor response.

The appearance of vitrification as a successful technique to freeze both oocytes and embryos has stirred new expectations in patients with a low response at the possibility of accumulating vitrified oocytes from several stimulation cycles. This way, after performing a number of oocyte collection cycles and once collecting a number between 6 and 8 oocytes has been achieved, the processes of fertilisation begin. In this case, prognosis is more favourable, as patients now have more or less the same number of oocytes as those patients with a normal response.

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2020-08-19T10:48:34+02:007 de July de 2020|0 Comments

What is ovarian reserve? What role does it play in fertility?

What is ovarian reserve?

Ovarian reserve can be defined as the number of ova in a woman’s
ovaries at any given point during her childbearing years.

In the case of men, spermatozoa production remains constant between puberty and senescence.  Recent studies confirm that spermatozoa quantity and quality can diminish over time. However, men generally remain fertile throughout their […]

2020-09-01T13:24:16+02:003 de July de 2020|0 Comments

Ovarian rejuvenation: myth or reality?

As a result of a number of different factors – essentially social and economic ones – including medical progress (availability and widespread use of contraception), there is a growing demographic trend in the Western world towards delaying when a woman tries for her first child. This translates into a number of different fertility issues that are caused […]

2020-07-13T15:35:56+02:0013 de June de 2020|0 Comments

Genetics in premature ovarian failure and menopause

Oocytes are the female gametes, cells that, upon being fertilised by the sperm, will produce an embryo. In humans, the number of oocytes that females have throughout their lives is not unlimited; they are born instead with a limited number. These oocytes gradually run out in each menstruation until their supply becomes completely exhausted at menopause.

It is said that women suffer from premature ovarian failure when menstruation ceases because the oocyte supply has become exhausted at an earlier age than the age when the natural decline of ovarian function occurs (at 50, approximately). In cases where oocytes are still produced in women suffering from premature ovarian failure, they do not respond satisfactorily to the hormones responsible for their development and maturation.

Premature ovarian failure may have important consequences for women:

Obviously, in their fertility: These women cannot conceive naturally and require assisted reproduction techniques in order to bear offspring. These patients also have a high risk that their oocytes will not respond to the In Vitro Fertilisation cycle, thus putting the success of the treatment in danger.On the other hand, the absence of female hormones due to low ovarian activity has serious consequences for health, mainly in cases of cardiovascular disease and osteoporosis.

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2020-08-17T17:28:13+02:005 de May de 2020|0 Comments
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