Implantation failure and repeated miscarriage unit

Implantation failure requires a specialized treatment that is provided at Instituto Bernabeu by a specific multidisciplinary unit.

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What is implantation failure?

It is defined as a failed attempt to achieve a viable pregnancy by means of IVF. That is, it encompasses both those patients who fail to become pregnant and those patients who become pregnant but have an early miscarriage.

Unidad de fallo de implantación embrionario

Why does embryo implantation failure happen?

It is a challenge to answer this question because we are unaware of many processes that result in a successful embryo implantation.

To begin with, it must be kept in mind that the cause cannot be attributed to a single patient (the mother) but to THREE: her, him and the embryo.

True, we know that some causes are related to the mother, but most of them have to do with the embryo, and they cannot always be diagnosed or treated satisfactorily. Hence the patient’s high degrees of uncertainty and anxiety when doctors cannot find them.

Nevertheless, great progress has been made in this field over the last years.

An accurate study of implantation failure requires a multidisciplinary assessment. For this reason, a working group that specializes in these disorders was created at INSTITUTO BERNABEU. This group includes gynecologists, endocrinologists, molecular biologists, geneticians and embryologists.

Implantation failure and repeated miscarriage unit

How are implantation failure and recurrent miscarriage studied at Bernabéu Institute?

It is necessary to assess the FEMALE FACTOR. Essentially, the study includes hysteroscopy, endometrial biopsy and/or culture transfer procedures; analysis of congenital or acquired thrombophilias; hormonal considerations, thyroid and karyotype functions. A complementary study may be necessary in certain cases.

We occasionally recommend studying the patient's individual response during a cycle prior to reproductive treatment. Two parameters are evaluated on the day of the cycle that will coincide with transfer. That is, progesterone levels - so that the dose or means of administration (vaginal or subcutaneous injection) can be adjusted - and contractions in the uterus. Should the latter be abnormal, they can be adjusted using pharmacological methods. Both studies facilitate optimising uterus receptivity in the mother with a view to improving embryo implantation.

THE MALE FACTOR is studied by karyotype, DNA fragmentation, and andrological examination and chromosome assessment.

But it is undoubtfully the EMBRYO FACTOR where the greatest advances have been made.

Indeed, these days molecular and genetic biology techniques make it possible to analyze all of the embryo’s chromosomes, as the most common cause for implantation failure and early miscarriage is an anomalous number and constitution of embryo chromosomes.

The transfer of chromosomally normal embryos makes pregnancy rates remain the same regardless of the mother’s age. At the same time, miscarriage risks decrease dramatically. In other words, whenever embryos that are free from chromosomal abnormalities are transferred, patients will always have the same expectancy for success regardless of their age.

This technique, known as CCS (Comprehensive Chromosomal Screening)(Preimplantation Genetic Screening (PGS), Preimplantation genetic testing for aneuploidy (PGT-A)), is used around the fifth day of the embryo’s development and is proving to be greatly effective to answer the most relevant questions for patients and for the doctors that take care of them.

Why do embryos fail to implant?

Why do they miscarry?

Is the treatment worth repeating?

Is it time to leave it or change it?

Comprehensive Analysis 1 day

Given our high degree of specialisation in recurrent pregnancy loss / implantation failure, we are able to bring together all the specialists involved in analysing your case during your medical consultation and carry out all the diagnostic tests required in order to analyse and design your personalised course of treatment in just one day.

     Female partner:

  • Hysteroscopy and, if necessary, endometrial biopsy.
  • Implantation failure genetic risk profile
  • Screening for trombophilia
  • Immunology analysis
  • Karyotype
  • Vitamin D levels
  • Evaluation of the uterus using high-resolution ultrasound imaging
  • Study, if appropriate, of uterine contractility and progesterone levels on the day of embryo transfer.

     Male partner:

  • Karyotype
  • DNA fragmentation study (TUNEL)
  • Sperm FISH

     Embryo profiling:


Personalized analysis of your medical history.

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