Upsala Journal of Medical Sciences prints a review carried out by Instituto Bernabeu regarding the role of GnRHa as ovulation induction, more than just to prevent hyperstimulation.

  • 27-05-2020

Optimizes and improves cycles for egg donors, oncology patients, women with low reserve, immature oocyte syndrome and empty follicle syndrome

The international medical journal Upsala Journal of Medical Sciences has just published a research paper led by Instituto Bernabeu entitled "Gonadotropin-releasing hormone agonist ovulation trigger — beyond OHSS prevention". It was developed by Instituto Bernabeu gynecologist, expert in ovarian stimulation, Dr. Juan Carlos Castillo with the participation of Thor Haahr, María Martínez-Moya and Peter Humaidan. The goal of this review is to present the advantages of the gonadotropin-releasing hormone agonist (GnRHa) trigger in ovarian stimulation during reproductive medicine treatment. It highlights that its role goes beyond the prevention of ovarian hyperstimulation syndrome (OHSS). 

The review carried out allows Dr. Castillo to indicate that the GnRHa trigger has had a fundamental role in changing ovulation induction policies worldwide, not only for the patient who undergoes in vitro fertilization (IVF), but also for other groups such as egg donors, cancer patients, patients with low ovarian reserve and those who have immature oocyte syndrome or empty follicle syndrome. 

The specialist emphasizes that the activation of GnRHa has led to the development of new protocols, "enriching the arsenal of assisted reproduction treatments for the benefit of current and future patients." 

The review has evaluated the impact that GnRHa has on the increase of follicle stimulating hormone (FSH), mimicking what happens in a natural cycle, which in turn allows an improvement in egg performance and potentially embryos. Experts have verified, based on the available scientific evidence, that more eggs are obtained and effectively stimulate their maturation.

Gonadotropin-releasing hormone agonist ovulation trigger—beyond OHSS prevention

JC Castillo, T Haahr, M. Martínez-Moya, P. Humaidan

Upsala Journal of Medical Sciences - Instituto Bernabeu