IBgen sperm: spermatogenesis genetic study

The fertigenic study allow us to know the genetic cause of the alterations detected in the seminogram, analyzing 426 genes involved in the sperm development

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Male fertility and genetics

Male infertility affects around 10% of men and is the cause of reproductive problems in 50% of couples who attend an assisted reproduction clinic. Only around 40% of cases are diagnosed and genetics are behind the most frequent alterations, although only 15% can be detected.

Hence, Instituto Bernabeu has developed a panel of 426 genes that evaluates the main genes involved in spermatogenesis to complete the diagnosis of male infertility from the genetic point of view by personalizing in vitro fertilization (IVF) treatment.

How can this fertigenetic analysis help me in the sperm formation process?

Until now we only had the spermiogram to investigate male fertility and we were limited when it came to delving into the origin of the pathologies that cause it.

The analysis of the alterations’ genetic origin, which have previously been diagnosed in a spermiogram, allows us to know the causes of the reproductive problem.

This makes possible to individualize treatment based on the patient’s therapeutic needs and assesses the prognosis for a cycle of assisted reproduction.

It’s also key when deciding to adopt fertility preservation measures.

How is it done and what is it about?

To carry it out, only DNA from the male is required, either through a blood or saliva sample.

If it’s not possible for you to come to our clinics, you can take the saliva sample yourself, allowing you to enjoy the comfort and discretion of your home

Once the biological sample reaches our laboratories, the DNA is extracted. Using sequencing techniques (NGS) the complete sequence of the 426 involved in spermatogenesis is obtained.

Then, a bioinformatic study of the identified genetic mutations is carried out to assess their pathogenicity and to be able to inform about the reproductive prognosis of the patient.

In addition, it allows to complement other results of genetic studies of the male such as, for example, karyotype and FISH or seminal TUNEL.

The most complete genes analysis related with male fertility

Until now, only very few genes could be analysed in order to know the genetic origin of male reproductive failure.

Advances in molecular biology and the development of massive sequencing techniques – together with the constant investment of the most avant-garde technology of Instituto Bernabeu – have allowed us to design the most complete genetic study of male fertility, identifying a total of 426 related genes with male gametogenesis.

Who is the fertigenetic IBgen sperm study recommended for?

It’s indicated for patients who, faced with an altered spermiogram, seek to know the origin and the most appropriate diagnosis for their case.

For example, in patients diagnosed with:

Azoospermia.
Severe oligozoospermia.
Asthenozoospermia
Oligoteratozoospermia

It would allow the adoption of therapeutic measures, mainly:

In the event when the patient must undergo a testicular biopsy or FNAB; and in then predict the probability of locating sperm.
In the event of a deleterious effect over time, know its evolution in order to take preventive measures.
Personalize your assisted reproduction treatment.