At Institute Bernabeu, we base our clinical practice and research on individualisation. This subspecialty has allowed us to diagnose and treat uncommon conditions, making us the leading centre for a number of pathologies.
Up until a few years ago, Klinefelter's Syndrome with a homogenous 47 XXY karyotype was considered absolute male sterility. In our group, we are constantly researching and developing new lines of treatment that allow for biological paternity in men suffering from Klinefelter's Syndrome.
At Instituto Bernabeu, we have a complete medical team dedicated to evaluating:
We can accept failure, but only after exhausting all possibilities available with clinical and technical advances. We would extensively inform you of these options and alternatives in your case.
In certain studies published, sperm was retrieved in almost 50% of patients and the pregnancy rate after ICSI was no different than that of cycles carried out for other types of sperm insufficiency. The rate of sperm retrieval seemed to be better in younger patients.
More recent studies are more modest in their results, apart from detecting massive fibrosis and hyalinization, which are found in all men suffering from Klinefelter's Syndrome, showed spermatogonia in 4 of the 22 men, with sperm differentiation in 2 of them.
We are aware of the high rates of infertility, but there is a possibility of obtaining sperm through a biopsy called TESE. The risk of malformation is the same as in any assisted reproduction technique.
Our goal is to obtain sperm in the most complex cases, but it should be taken into account that the risk of complications could increase due to the more aggressive process. We inform you in detail about all of these possibilities. A large part of the testicular parenchyma is exposed in order to detect the more vascularised part.