R+D+I: Essais cliniques de l’Instituto Bernabeu

Un traitement médical correct doit combiner, avec les soins purement médicaux, la personnalisation du processus et, dans certains cas, l'application de la R+D+I. À l'Instituto Bernabeu, nous menons en permanence différentes lignes de recherche auxquelles nos patients peuvent s'inscrire s'ils le souhaitent.

Instituto Bernabeu ensayos clínicos

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Machine learning and euploid embryo implantation

Machine learning and euploid embryo implantation

Investigation subject: human embryos from in vitro fertilisation (IVF) cycles whose chromosomal endowment has been analysed by PGT-A.

Objective: exemplary Machine Learning algorithms to predict the probability a euploid embryo (analysed by PGT-A) will implant in the maternal uterus. Different patient characteristics (maternal and paternal), IVF cycle, embryos, ovarian stimulation and embryo biopsy will be used as predictor variables.

Current situation: The number of cases is currently being expanded and after the appropriate statistical analysis.

Location: Molecular Biology and Genetics department. Instituto Bernabeu. Alicante.

Coordinated by: Dr Jose A. Ortiz, Dr Ruth Morales and Dr Belén Lledó.

Meta-analysis and systematic review of factors associated with embryonic mosaicism

Meta-analysis and systematic review of factors associated with embryonic mosaicism

Investigation subject: possible factors, such as maternal and paternal age, semen quality, embryonic quality or the day of biopsy that could be associated with embryonic mosaicism.

Objective: to perform a systematic review of the available scientific literature related to the possible factors associated with embryonic mosaicism, with its corresponding meta-analysis.

Current situation: embryonic mosaicism (presence of two or more chromosomally different cell lines in the embryo) has become a topic of great interest in recent years, due to the fact that a percentage of the embryos analyzed by PGT-A are diagnosed as mosaics. This has generated continuous research in this field,to try to find out the causes and factors that may be associated with this phenomenon.

Location: Instituto Bernabeu Alicante.

Coordinated by: Dr Ruth Morales and Dr Belén Lledó.

Correlation between clinical findings and embryonic chromosomal status by non-invasive analysis

Correlation between clinical findings and embryonic chromosomal status by non-invasive analysis

Investigation subject: prospective randomised study investigating chromosomal analysis of embryos transferred into the maternal uterus using non-invasive techniques.

Objective: toestablish a correlation between the chromosomal status of the embryo transferred to the maternal uterus and its potential for implantation and evolutionary gestation.

Current situation: recruitment phase.

Location: Instituto Bernabeu Alicante.

Coordinated by: Dr Belén Lledó, Dr Dori Rodríguez, Dr Jorge Ten.

Predictive model for chromosomal abnormalities

Predictive model for chromosomal abnormalities

Investigation subject: human embryos from in vitro fertilisation (IVF) cycles whose chromosomal endowment has been analysed by PGT-A.

Objective: topredict the probability of an embryo being euploid (chromosomally normal) from different patient data, IVF cycle and embryo morphological characteristics.

Current situation: pending for publication

Location: Instituto Bernabeu’s Molecular Biology and Genetics department. Alicante.

Coordinated by: Dr Jose A. Ortiz, Dr Ruth Morales and Dr Belen Lledo.

Assessment of clinical outcomes after IBgen FIV

Assessment of clinical outcomes after IBgen FIV

Investigation subject: clinical and ovarian stimulation results of patients who have undergone the IBgenFIV test.

Objective: the main objective of this study is to test the efficacy of the IBGenFIV test in improving clinical data and thus to find out if it’s clinically useful.

Current situation: statistical analysis.

Location: Instituto Bernabeu’s Molecular Biology and Genetics department. Alicante.

Coordinated by: Dr Belen Lledo and Dr Jose A. Ortiz.

Whole-exome sequencing in premature ovarian failure

Whole-exome sequencing in premature ovarian failure

Investigation subject: Identification of novel variants and candidate genes in women with familial idiopathic premature ovarian failure (cessation of menstruation before age 40) using whole-exomesequencing (WES).

Objective: To identify a genetic cause of familial premature ovarian failure (POF) with whole-exome sequencing.

Current situation: Premature ovarian failure is a common cause of infertility in women. This pathology has a heterogeneous etiology. Some chromosomal and genetic alterations have been described, and could explain approximately 20% of cases. However, in most patients the origin remains unknown. Recent studies with next-generation sequencing (NGS) have identified new variants in candidate genes related with premature ovarian insufficiency (POI) or premature ovarian failure (POF). These genes are not only involved in processes such as folliculogenesis, but also with DNA damage repair, homologous recombination, and meiosis.

Location: Instituto Bernabeu Alicante.

Coordinated by: Dr Ruth Morales and Dr Belén Lledó.

Influence of group embryo culture versus individual embryo culture on blastocyst quality and rate of blastocyst formation

Influence of group embryo culture versus individual embryo culture on blastocyst quality and rate of blastocyst formation

Investigation subject: whether there’re differences in the development and quality of individually and group cultured embryos.

Objective: todetermine which method of embryo culture (single or group) up to day 5 is best to achieve the highest quality and rate of blastocyst formation.

Current situation: Embryos database.

Location: IB Alicante.

Coordinated by: Miguel Herreros, Laura Martí, Nerea Díaz, María del Carmen Tió, Dr Adoración Rodríguez, Jaime Guerrero, Dr José Ortiz, Dr Jorge Ten y Dr Rafael Bernabeu.

Does the trophectoderm biopsy technique affect the result of the genetic analysis in PGT-A cycles?

Does the trophectoderm biopsy technique affect the result of the genetic analysis in PGT-A cycles?

Investigation subject: compare significant genetic results of the biopsied embryos that could be influenced by the biopsy technique “pulling” or “flicking”, in order to choose the better.

Objective: compare the two biopsy techniques currently used in our laboratories.

Current situation: collecting last data (babies born in 2021).

Location: IB Madrid.

Coordinated by: Leyre Herrero, Laura Cascales, Mónica Aparicio, Dr Jorge Ten.

Importance du compactage endométrial après l’exposition à la progestérone en cycle substitué pour le transfert des embryons

Importance du compactage endométrial après l’exposition à la progestérone en cycle substitué pour le transfert des embryons

Qu’est-ce qu’elle étudie ? :  Elle étudie l’éventuelle importance des changements endométriaux qui se produisent après l’exposition à la progestérone dans le développement et l’évolution postérieure d’une grossesse et si ces changements obéissent à une prédisposition génétique.

Objectif : Comparer les résultats reproductifs dans des cycles de préparation pour le transfert d’embryons entre les patientes qui réduisent leur endomètre dans la phase sécrétrice préalable au transfert et celles qui maintiennent un endomètre stable ou plus élevé.

Démarrage : juin 2021. Situation actuelle : en cours de recrutement de patientes de façon active.

Lieu : Institut Bernabeu Alicante, Madrid, Albacete, Majorque, Benidorm et Elche. 

Plus d’informations : Si vous voulez plus d’informations, cliquez sur le lien suivant

Stimulation conventionnelle en phase folliculaire versus stimulation en phase lutéale chez les patients ayant une réponse sous-optimale. Essai clinique randomisé. Étude sublinguale

Stimulation conventionnelle en phase folliculaire versus stimulation en phase lutéale chez les patients ayant une réponse sous-optimale. Essai clinique randomisé. Étude sublinguale

Maladie étudiée : réponse sous-optimale à la stimulation ovarienne.

Objectif : étudier la différence entre le nombre d’ovocytes obtenus par stimulation ovarienne en phase folliculaire par rapport à une stimulation en phase lutéale sur une population de patientes ayant déjà obtenu une réponse sous-optimale.

Date de début : janvier 2020

Lieu : Instituto Bernabeu Alicante

Plus d’informations : Si vous voulez plus d’informations, cliquez sur le lien suivant

Pour plus de détails sur l’étude, vous pouvez la consulter sur Ministère de la santé

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