IB Research: CCS as a means of achieving pregnancy in women who are polymorphism carriers.

Developments in Comprehensive Chromosome Screening (CCS) which provides information on the chromosomal make-up of embryos, have meant that we are able to determine which embryos have chromosome abnormalities and study possible factors affecting those abnormalities.

This research, which was accepted by the committee for the VIII edition of the ASEBIR Congress (Spanish Association for the Study of Biology and Human Reproduction) which took place in San Sebastian, Spain, in November, analyses the possible link between chromosome variants (polymorphisms) which are deemed normal and the percentage of chromosomally normal embryos from IVF cycles.  Further to analysis of chromosomal abnormalities (aneuploidy) on a large number of blastocysts, our data indicates a greater number of abnormalities in embryos from couples with polymorphisms in their karyotypes. Women who are carriers of polymorphisms are particularly at risk of having aneuploidy embryos. These do not implant properly or lead to pregnancy loss.

Therefore, and according to our results, CCS for carriers of polymorphisms in order to select chromosomally normal embryos would improve results in IVF cycles. This, in turn, would improve the chances of success in assisted reproduction techniques.

CHROMOSOMAL POLYMORPHISMS INCREASE ANEUPLOIDY RATES IN GAMETES AND EMBRYOS. R.Morales, B.Lledo, JA.Ortiz, A.Rodriguez-Arnedo, H.Blanca, J.Ll. Aparicio, R.Bernabeu.