The Manager of the Embryology Unit at Instituto Bernabeu, Dr Jorge Ten, has given a lecture on the Master’s Course in Human Reproduction organised by Complutense University in Madrid (UCM) and the Spanish Fertility Society (SEF). The doctor has been actively involved in course for over a decade. Dr Ten addressed the issue of oocyte vitrification. Instituto Bernabeu is a groundbreaking clinic in this field with over fifteen years of experience of vitrification of both gametes and embryos. Practices such as these need to be performed under a robust vitrification programme and by experienced embryologists. The Master's Course, in which Instituto Bernabeu plays an active role, trains students in highly specialised reproductive medicine skills and updates their scientific knowledge.
The Instituto Bernabeu Group has obtained the ISO 14001:2015 Environmental Management System Certificate in all its clinics; Alicante, Madrid, Palma de Mallorca, Albacete, Cartagena, Elche and Benidorm.
Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu and expert in poor ovarian reserve; Dr Juan Carlos Castillo, a specialist in ovarian stimulation; and Cristina García-Ajofrín, a gynaecologist at IB in Madrid and an expert in uterine causes of infertility, have given three master classes to students on the University of Alicante and Instituto Bernabeu Master's degree in Reproductive Medicine.
A woman’s ovarian reserve is the number of viable oocytes that she has in her ovaries at any given time. This figure conditions the quantity of ova that can be retrieved during in vitro fertilisation treatment. As a woman ages, her ovarian reserve decreases and this is why the Medical Director at Instituto Bernabeu, Dr Rafael Bernabeu, has emphasised the importance of this factor and encouraged both experts in the field and patients to be keenly aware of this before it is too late.
Instituto Bernabeu participated in a gathering of experts at the ‘Endometriosis and infertility: the extent of the problem’ ESHRE Campus held in Milan on 23rd and 24th January 2020. The scientific event, organised by the European Society of Human Reproduction and Embryology’s endometriosis and endometrial disorders work group, selected research work carried out by Instituto Bernabeu as a candidate for the best poster award. Dr Belén Moliner, the clinic's expert in endometriosis, attended the meeting in order to answer questions about the research work: ‘The inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure with endometriosis and without it.’
Instituto Bernabeu researchers have studied the impact of the male factor on embryo mosaicism or cases of embryos with some normal cells and some chromosomally abnormal cells. It is one of the reasons for implantation failure but the factors that cause it remain unclear. The aim of the study was to assess which male factors could have an impact on embryo mosaicism rates.
The Embryology and Reproductive Medicine Units at Instituto Bernabeu are leading research aimed at determining if a reasonable number of good quality blastocysts (embryos on days 5 to 6 or development prior to implantation) can be retrieved following culture and observation of oocytes that have not fertilised correctly. In in vitro fertilisation laboratories, around 20% of inseminated oocytes suffer fertilisation failure and 3% of oocytes fertilise abnormally.
Instituto Bernabeu has undertaken a research project that aims to analyse if using probiotics could improve pregnancy rates in assisted reproduction treatment. To this end, the clinic has performed a study involving a group of patients with a recurrent implantation failure (RIF) diagnosis, plus another group of patients with no such diagnosis.
Instituto Bernabeu has participated in a professional event for general health and reproductive medicine specialists. The clinic addressed the procedures it adheres to for egg and sperm donation, in addition to means of achieving improved results. The congress was entitled ‘Means of diagnostic and therapeutic healthcare in assisted reproduction procedures and synergies between specialists in the field.’ Instituto Bernabeu addressed the requirements for and access to heterologous artificial insemination through egg donation, sperm donation and embryo adoption.
The genetics laboratory at Instituto Bernabeu is using next-generation sequencing to find out what is behind unknown causes of sterility. In 2020, Instituto Bernabeu will continue with work on the research into this subject that it started in 2018. Instituto Bernabeu points out that next-generation sequencing can be used to work out what causes sterility when other conventional clinical diagnoses techniques cannot.
Instituto Bernabeu research aimed to determine if any ovarian stimulation factors can be linked to oocyte morphology and to the type of membrane breakage when intracytoplasmic spermatozoa injection (ICSI) is performed. This assisted reproduction technique is routinely used in in vitro fertilisation (IVF) laboratories. It has the huge advantage of providing a helping hand when male patients suffer from severe male factors and it stops sperm counts from being a limitation. However, the main disadvantage is that the results depend to a large degree on the operator performing the technique. Although specialists are currently able to perform the process securely, there are some variations in the results that they obtain. Differences between oocytes in ICSI are observed even when an egg donation programme is used.
The new Instituto Bernabeu Group newsletter is now available. Microbiome analysis in patients with embryo implantation failure.
Instituto Bernabeu in Cartagena is organising a scientific event to address progress in the treatment of uterine fibroids. The event will be held on Friday, 31st January in the graduation room at the Polytechnic University in Cartagena. This is just one of many scientific events that the clinic regularly organises at its Cartagena branch. The purpose of the events is to improve knowledge of reproductive health.
Instituto Bernabeu is set to employ a new technique that helps women under 35 years of age to have children with their own ova. These women are otherwise compelled to turn to egg donation
Instituto Bernabeu's social welfare entity invests over €123,000 in courses of treatment for patients who have limited financial resources. This is over 70% of the €176,000 total spend. It donates €33,500 to NGOs, €14,200 to science and research and €10,000 to student scholarships.
Instituto Bernabeu’s participation in events held in Portugal on 4th and 5th December focused on poor responders and new strategies to help women achieve a pregnancy.
Does the number of oocytes obtained following ovarian puncture have an impact on embryo quality? This is the question that a team of researchers from the Embryology Departments at Instituto Bernabeu in Alicante and Albacete and the genetics laboratory at Biotech asked themselves as they proceeded to study the results obtained in almost 400 cycles of in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). The research work was presented in poster format at the Association for the Study of Reproduction Biology (ASEBIR) Congress, a gathering attended by leading global experts. The research was based on the relationship between the number of oocytes obtained following ovarian puncture and the results of IVF treatment.
Dr Rafael Bernabeu, Medical Director at Instituto Bernabeu, gave a speech within the framework of the ‘Review and updated handling of recurrent pregnancy loss’ course held in Madrid. The event was organised by the Spanish Society of Gynaecology and Obstetrics (SEGO).
A team of researchers from the Embryology and Reproductive Medicine Units at Instituto Bernabeu in Madrid and Alicante have completed a study of the factors that may have the greatest impact on embryo transfer rates following a cycle of assisted reproduction. The research work was presented at the Association for the Study of Reproduction Biology (ASEBIR) Congress held in late October in Cáceres.
The aim of research work performed by the Genetics and Molecular Biology Department at Instituto Bernabeu IBBiotech was to determine if there is a relationship between the ovarian stimulation process in cycles of in vitro fertilisation (IVF) and the aneuploidy and mosaicism rate in embryos. The conclusions were presented at the Association for the Study of Reproduction Biology (ASEBIR) Congress held in October in Cáceres.
Instituto Bernabeu gave an oral communication about oocyte vitrification at the Association for the Study of Reproduction Biology (ASEBIR) Congress held in Cáceres in October. Freezing is common practice during in vitro fertilisation (IVF) treatment because it increases the available number of blastocysts for analysis.
Instituto Bernabeu’s strive for excellence is clearly marked out in a meticulous work method and implementation of the most demanding healthcare and process quality controls with the aim of always achieving excellent results. The healthcare that patients are given is endorsed by certifications and accreditations awarded to the clinic by independent entities. Instituto Bernabeu Group has recently been awarded the QH* accreditation. It entails not only a renewal of the Quality Healthcare (QH) certification, but also an additional, higher level that has been driven by the ‘increase in the validity of certain certifications’, as highlighted by the Institute for Development and Integration of Health (IDIS), the accrediting organism.
Instituto Bernabeu gave an oral communication at the European Society of Human Reproduction and Embryology (ESHRE) Congress entitled ‘The luteal phase of double ovarian stimulation treatment (DuoStim) provides higher oocyte and blastocyst yield in unselected infertile patients: a retrospective, same-patient, cohort study.’ This study is included in the articles that Merck has featured in its specialist journal focussing on fitting publications that is released following the scientific gathering focussing on fitting publications.
Instituto Bernabeu attended the Association for the Study of Reproduction Biology (ASEBIR) Congress held in Cáceres and presented a study about the effect that segmental chromosomal aneuploidies have on the embryo.
Once again this year, Instituto Bernabeu attended the Association for the Study of Reproduction Biology (ASEBIR) Congress. It was held in Cáceres from 23rd to 25th October 2019. Nine items of research work performed by the Embryology Unit and the Molecular Biology and Genetics Department were presented at the national congress. It is the most significant congress of its kind in the field of reproduction biology.
Instituto Bernabeu attended the World of Microbiome Pregnancy, Birth and Infancy congress held in Milan, Italy from 31st October to 2nd November. Dr Belén Lledó, Scientific Director of IBBiotech presented Instituto Bernabeu’s pioneering research into the impact of the vaginal microbiome on the results of assisted reproduction treatment.
Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu, moderated the Endometrial Receptivity Workshop held within the framework of the 4th Clinical Workshops on Reproduction Medicine organised by Ferring and held in Valencia on 8th and 9th November.
Instituto Bernabeu has submitted a pilot study involving ova donors to the European Society of Human Reproduction and Embryology (ESHRE). It researches differences in results when conventional ovarian stimulation protocols are applied in comparison with new, no fixed time stimulation protocols that do not take the stage of the menstrual cycle into account. The research entailed an analysis of ova donation cycles which was performed over ten months. It compared stimulation beginning on days 1 to 3 with ovarian stimulation that had no fixed time from day 4 onwards.
The Rafael Bernabeu Social Welfare Foundation has published the results of the 2018-2019 scholarships awards. The scholarships provide Medicine, Nursing, Biology and Biotechnology students in Spain with financial support in order boost their studies. On this occasion, further to assessment of all the applications that were received, the Awards Committee chose to award four students the scholarships worth a total of 10,000 euros.
Instituto Bernabeu participated in the 75th edition of the American Society for Reproductive Medicine (ASRM) congress held from 12th to 16th October in Philadelphia. It is one of the leading congresses in the world both in terms of the number of participants and in terms of the quality of the work that is presented there. Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu, was the clinic representative at the global gathering of experts attended by 9,300 people from 94 countries. It is a not-to-be-missed event in the field.
The recent international congress Meeting The Experts provided relevant reviews and information on the latest scientific advances in the treatment of reproductive problems. We were able to interview all the speakers that clarified these aspects. Here are all the videos of the interviews to broaden and complete their contribution.
Dr Rafael Bernabeu, Medical Director of Instituto Bernabeu, has addressed medical and healthcare aspects of cross-border reproductive medicine in a gathering of experts in law organised by the University of Alicante (UA). The seminar, entitled ‘Multi-disciplinary outlooks for studying healthcare in cross-border reproduction’, was held on 23rd September and gynaecologist Dr Bernabeu delivered the specialist’s point of view on the subject. The event was organised by the Department of Civil Law and it was attended by full professors and associate professors in Sociology and Civil Law.
Pharmacogenetics and Genomics, a specialist journal, recently published Instituto Bernabeu research work into ovarian reserve and pharmacogenetics, a subject in which the clinic is a leading entity and pioneer. The research was managed by Dr Belén Lledó, Scientific Director of Instituto Bernabeu Biotech, and it addressed the relevance of individual screening of the genetic variants in terms of ovarian response prediction. The aim was to determine if the polymorphisms in some genes involved in ovarian follicle maturation can predict ovarian response.
The Journal of Assisted Reproduction and Genetics (JARG) has cited the conclusions that were reached during the research
Instituto Bernabeu has brought the third edition of the international Meeting the Experts event for specialists in the field of reproductive medicine (27th and 28th September) to a close. The event was held in the Alicante facilities and 140 experts including gynaecologists, geneticists, biologists, molecular biologists, pharmacists and artificial intelligence specialists from China, USA, Australia, Israel, Belgium, Norway, Denmark, England, Italy and Switzerland met there to exchange knowledge and experiences.
Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu, participated in Next Now Theramex Fertility held in Valencia on 20th and 21st September. International experts in the field attended the professional event. Dr Llácer, who is a gynaecologist, addressed the impact of genetic polymorphisms on ovarian response. Poor ovarian reserve is one of the most common issues in the field of reproductive medicine and Dr Llácer is a renowned specialist in this area. He manages the department dedicated to this issue at Instituto Bernabeu.
Instituto Bernabeu has submitted research work about optimisation of ovarian stimulation in oocyte donation cycles to the European Society of Human Reproduction and Embryology (ESHRE). The research involves using oral progesterone instead of the GnRH antagonist, the alternative pharmaceutical drug that has traditionally been used to control when ovulation takes place. The main advantage of this strategy is how easy it is for patients because it entails fewer injections.
Dr Jorge Ten, Manager of the Embryology Unit at Instituto Bernabeu, will participate today, Tuesday 17th September, in a CooperSurgical workshop held in Valencia and entitled ‘Experiences using LifeGlobal Total LP (5mg) Culture Media’. The event on embryo culture brings together embryology managers so that they can present their experience and most recent results with this embryo culture and transfer medium.
The August 2019 issue of the Journal of Assisted Reproduction and Genetics (JARG) referenced research work about abnormal sperm analysis using the FISH (fluorescence in situ hybridisation) diagnosis technique and in which Instituto Bernabeu is participating. This specialist journal, which is published by the American Society of Reproductive Medicine (ASRM), accepted the research on the use of FISH in assisted reproduction techniques which involves analysis of part of the chromosomal make-up of spermatozoa.
Instituto Bernabeu has submitted research work to the European Society of Human Reproduction and Embryology (ESHRE), the leading worldwide entity in the field of reproductive medicine. The purpose of the research was to understand if using Embryoglue® as the culture medium for embryo transfer to the mother's uterus improves results.
Instituto Bernabeu is unrelenting in its research work and its trials are featured in leading congresses in the field of reproductive medicine.
Instituto Bernabeu’s seventh reproductive medicine clinic has opened in Palma de Mallorca. It is located in Avenida de Aragón, number 8, right in the commercial heart of Mallorca, opposite El Corte Inglés. The clinic specialises in personalised solutions and courses of fertility treatment that have been designed to suit each patient. Its branch in Mallorca uses the very latest developments in the field of genetics and reproductive medicine. Its treatment units, such as the Poor Ovarian Reserve Unit and Embryo Implantation Failure Unit are internationally renowned.
For a further year, the European Society of Human Reproduction and Embryology (ESHRE) has summoned a broad group of specialists from Instituto Bernabeu to take part in their scientific round table discussions and debate groups concerning infertility at the largest reproductive medicine and embryology scientific conference held in 2019. Our clinic experts, who contributed their own scientific papers, have thus collaborated in the development of reproductive medicine for a further year.
The new Instituto Bernabeu Group newsletter is now available. Thanks to a flawless technical test and a highly regarded report, our embryo PGT-A (pre implantation genetic test) screening was awarded the top score.
Instituto Bernabeu and the University of Alicante (UA) will manage the 8th edition of the Master's Course in Reproductive Medicine for the 2019-2020 academic year. The aim is to provide experts from the world of health sciences with excellent and comprehensive training in the field of reproductive medicine.
Students from the 7th Reproductive Medicine Master's Degree by University of Alicante (UA) and Instituto Bernabeu have concluded their 2018/2019 course with a closing ceremony held at the clinic's premises.
Next September 2019 will see a number of renowned, worldwide experts in the different reproductive medicine areas meet at Instituto Bernabeu's III International Meeting the Experts conference. This triennial event is aimed at sharing new fertility related developments and knowledge with the purpose of attaining a renewed approach concerning the most important challenges facing reproductive medicine.
Instituto Bernabeu undertakes vital healthcare work which is supplemented by its participation in congresses and both national and international events. One of this month's most relevant event took place in Cordoba. The 7th SEF National Meeting of Groups of Interest was held on 7th and 8th June. Every two years, the Spanish Fertility Society brings together experts in assisted reproductive medicine in order to share updated ideas and make new contributions across various fields.
The genetics laboratory at Instituto Bernabeu has been awarded the highest possible mark in an assessment of its PGT-A genetics test by an external and independent European organism. The assessment was performed anonymously on 56 European laboratories. The PGT-A test assesses if the embryo is chromosomally normal or aneuploidy. It is recommended for women who are older when having children; women who have a background of recurrent pregnancy loss; and women who have suffered from implantation failure. This test is also recommended for couples who have chromosomal abnormalities.
Leading experts worldwide in the field of infertility will gather in Vienna in June. The event is unmissable for Instituto Bernabeu since the clinic will play an active role and will make research work developed by the clinic public.
The new Instituto Bernabeu Group newsletter is now available. Our group will be actively present at the 35th edition of ESHRE in June. The scientific committee has accepted 9 clinical studies borne of the team of human resources at Instituto Bernabeu based on our research work that focuses on poor ovarian reserve and embryo implantation failure.
Dr Jorge Ten, Director of the Embryology Unit, participated in a gathering of specialists who debated the main trends in terms of techniques and protocols for treating patients who have a difficult prognosis.
The next 27th and 28th September will take place the 3rd Edition of "Meeting the Experts", the international reproductive medicine conference organized by Instituto Bernabeu.
Instituto Bernabeu has participated in the first edition of the Master's Course in Primary Healthcare at the University Of Castilla La Mancha (UCLM) with an intervention on latest developments in the field of reproductive medicine. The specialist training course is aimed at general practitioners, resident doctors and nursing students and its objectives include increasing participants’ capacity to resolve most of the problems presented by patients who request appointments with their general practitioner, the most proximate level of healthcare. The Master's Course includes updates on the latest developments in terms of diagnosis and treatment in primary healthcare. It is for this reason that gynaecology and reproductive medicine play a significant role.
Leyre Herrero, our Head of Human Biology laboratory in Instituto Bernabeu Madrid, will lead a practical theoretical workshop this Thursday where the protocol Kitazato on vitrification and devitrification will be addressed. The training session will take place in Marbella at the HC International Hospital.
Instituto Bernabeu has been included as a Quality Clinic on the Autonomous Community of Valencia Official Register of Health Clinics. This means that the clinic has been included on the Autonomous Community of Valencia Register of Quality Certifications for Health Clinics, Services and Establishments. It covers, on the one hand, the ISO 9001:2015 certification that the clinic was awarded in January 2016 for ‘Provision of assisted reproduction clinic healthcare, gynaecology consultations and pregnancy control. Performing molecular biology, andrology laboratory, semen bank, oocyte bank and embryo bank activities.’ On the other, the Autonomous Community Register has added UNE-EN 179006:2013 for ‘Management of patient safety risks’, awarded in December 2015.
Research that was carried out by the Genetics Unit at Instituto Bernabeu Biotech and entitled ‘Mosaic segmental aneuploidies in trophectoderm cells do not affect pregnancy rates in cycles of in vitro fertilisation (IVF)’ has been selected as one of the best oral presentations at the 2nd Human Genetics Interdisciplinary Congress held in Madrid between 3rd and 5th April 2019.
Instituto Bernabeu presents research work on the impact of mitochondrial DNA when predicting an embryo's ability to implant at the 18th Congress of the Pre-implantation Genetic Diagnosis International Society
The Genetics Department at Instituto Bernabeu was present at the 18th International Conference on pre-implantation genetics organised by the Pre-implantation Genetic Diagnosis International Society (PGDIS) and held in Geneva (Switzerland) between 15th and 18th April. Leading experts in reproductive biology, genetics and embryology met at the event which addressed development of pre-implantation genetic testing (PGT) technology.
Medical Co-Director of Instituto Bernabeu, Dr Joaquín Llácer, and Dr Paolo Cirillo participated in the 2nd National Congress of the Reproductive Medicine Foundation of Italy (PMA) held in Florence on 21st and 22nd March. Dr Llácer, an expert in poor ovarian reserve, gave a conference delivered to specialists in assisted reproduction that addressed the ‘Challenges of treating patients with poor ovarian response.’
Instituto Bernabeu participated in the 20th Human Reproduction Event held in Cuenca on 21st and 22nd March and organised by the European Fertility Institute. Reproductive medicine professionals from clinics in Madrid attended the event. The Head of the In Vitro Fertilisation (IVF) Laboratory at Instituto Bernabeu in Madrid and Instituto Bernabeu biologist, Iván Ochando, attended the event where participants discussed, debated and were updated on matters within the field of assisted human reproduction.
Instituto Bernabeu in Albacete participated in the Gynaecological Ultrasound Scan Workshop organised by the University of Castilla La Mancha within the framework of its Master's Course in Primary Healthcare. María Antonia López Rubio, a doctor at the clinic in Albacete, was responsible for teaching some of the finer details of clinical practice at Instituto Bernabeu to students on the specialist training course.
The Scientific Director of Instituto Bernabeu Biotech, Dr Belén Lledó, gave a conference entitled ‘The importance of genetics in early diagnosis’ within the framework of the 1st Scientific Event ‘Understanding Disability: the importance of early diagnosis in intellectual disability and neurodevelopmental disorders’ held at Miguel Hernández University (UMH) in Elche. The gathering was organised by the Tempe/ASPA Disability and Employability Chair at UMH. Dr José Antonio Ortiz, Head of the Molecular Biology Department at Instituto Bernabeu, was also present and moderated the lecture.
The congress sponsored by the European Society of Human Reproduction and Embryology (ESHRE) and the world’s most important gathering for experts in the field has selected three doctors from Instituto Bernabeu for the role of scientific research reviewers. The reproductive medicine clinic participates annually in this essential gathering for leading researchers in the field of fertility by presenting scientific research on infertility, genetics and embryology, amongst others. Furthermore, Medical Co-Director of Instituto Bernabeu, Dr Joaquín Llácer, is a spokesperson on the society’s committee of representatives and the Spanish specialists’ representative at ESHRE until 2020.
The Manager of the Embryology Unit at Instituto Bernabeu, Dr Jorge Ten, gave a lecture on the Master’s Course in Human Reproduction organised by Complutense University in Madrid (UCM) and the Spanish Fertility Society (SEF).
Instituto Bernabeu's gyneacologists specialised in reproductive medicine, participated in the course on Treatment of the Sterile Partner that was held on 1st March in the Madrid headquarters of the Spanish Society of Gynaecology and Obstetrics (SEGO). The training course is for gynaecologists who are interested in reproductive medicine. It is organised by the Sterility and Infertility section at SEGO and Dr Rafael Bernabeu, Vice President of SEISEGO, addressed the issue of diagnostic guidance.
Instituto Bernabeu in Albacete is actively involved in the community in Castilla La Mancha. Its work includes talks, workshops and courses in which staff from the reproductive medicine clinic participate. Instituto Bernabeu researchers collaborate and participate in the training courses for future specialists and they help to teach them the techniques and processes that are used in reproductive medicine.
In February, Dr Joaquín Llácer, our Medical Co-Director, participated in two events aimed at reproductive medicine specialists. On 2nd February in the 3rd Galician and Portuguese Event on Assisted Reproduction, the gynaecologist who specialises in poor ovarian response gave a presentation addressing demeanour when dealing with patients who have a poor assisted reproduction prognosis. Spanish and Portuguese specialists gathered at the event in order to address legislative challenges, the challenges faced by reproductive medicine and some of the field’s ethical debates.
Human Reproduction, a scientific journal, has published research work carried out by Instituto Bernabeu that examines whether or not the number of mitochondrial DNA copies (mtDNA) in human embryos can affect pregnancy rates. The clinic is the first to have performed a comprehensive study of embryo mtDNA linked to IVF results analysing the quantity and quality of the mtDNA.
We have launched a new issue of Instituto Bernabeu corporate newsletter "IB Newsletter". Pregnancy and childbirth guarantee programme or 100% reimbursment.
Instituto Bernabeu research has looked into reducing uterine hypercontractility prior to embryo transfer and if administering Atosiban helps patients with this issue. The results of the research work entitled ‘Treatment of uterine hypercontractility with Atosiban during embryo transfer’ were presented at the 1st National Congress of the Spanish Infertility and Sterility Society (SEISEGO).
Instituto Bernabeu researchers have presented experience of a clinical case that describes uterine incarceration, a very infrequent complication during pregnancy. They gave their presentation at the 1st National Congress of the Spanish Society of Gynaecology and Obstetrics (SEISEGO) that was held within the framework of the Spanish Society of Gynaecology and Obstetrics Congress (SEGO). Uterine incarceration occurs during pregnancy when the uterus becomes wedged into the pelvis. There are very few available described cases of this complex and serious condition that is difficult to diagnosis. As such, this study is a very valuable contribution towards improving our understanding of it and advising medical staff about when the symptoms arise.
Dr Rafael Bernabeu, Medical Director at Instituto Bernabeu, has participated in the 20th Intellectual Property and Innovation Congress. The event fosters development in various innovation-intensive industries and it is held at the University of Alicante campus in Calle San Fernando 40. The event is organised by the European Intellectual Property Institutes Network (EIPIN) and it brings together international experts from a wide range of fields of intellectual property, innovation and patents.
We have launched a new issue of Instituto Bernabeu corporate newsletter "IB Newsletter". Rafael Bernabeu Charitable Foundation opens the call for its scholarships for university students endowed with 45.000 euros. Students of Medicine, Nursing, Biology and Biotechnology of Universities from all over the country, that have brilliant trajectories and whose family income is an obstacle to continue their studies.
Azoospermia is one of the causes of male sterility. In order to be able to retrieve spermatozoa in men with this condition, the man has to undergo techniques involving sperm aspiration from the epididymis or testicles, or a testicular biopsy. Although these techniques can be performed at any time and the samples can be cryopreserved for use in the future, with our patients we generally aim to synchronise the procedure with oocyte retrieval. When we do so, the procedure can be performed the day before or the same day as the ovarian puncture that is used to retrieve oocytes from the female partner. Researchers at Instituto Bernabeu carried out a study to find out which of the two days chosen for testicular spermatozoa retrieval gave the best clinical results. The research work was presented to the 1st National Congress of the Spanish Society of Gynaecology and Obstetrics (SEISEGO) that was held within the framework of the Spanish Society of Gynaecology and Obstetrics Congress (SEGO).
A team of gynaecologists, embryologists, molecular biologists and biologists at Instituto Bernabeu has carried out research to determine if there is an increased number of monozygotic twin pregnancies following transfer when an embryo biopsy during the blastocyst stage (day 5 or 6 of development) has been performed. The twins come from a single ovum or single spermatozoon and they have the same genetic make-up. Pregnancies of this kind are also linked to various perinatal complications.
Instituto Bernabeu has presented research work analysing the clinical results obtained in an oocyte donor programme following random-start ovarian stimulation in comparison with conventional ovarian stimulation to the Sterility and Infertility Section of the Spanish Society of Gynaecology and Obstetrics (SEISEGO). Researchers at the reproductive medicine clinic discovered that there are no significant differences between the results and they highlight that this is an advantage for commencing treatment and synchronising the donor and recipient.
The Rafael Bernabeu Foundation has launched the edition of its €45,000 university student scholarship programme.
Embryo aneuploidies are one of the main causes of failure during in vitro fertilisation (IVF) treatment. Most of the errors that lead to embryos with chromosomal abnormalities have a maternal origin and numerous studies suggest that the mother’s age is a decisive factor. Instituto Bernabeu research work that was presented at the 1st National Congress of the Spanish Infertility and Sterility Society (SEISEGO) has gone a step further. It questions if ovarian stimulation can have an impact on embryo chromosomal abnormalities.
The Spanish Society of Gynaecology and Obstetrics has published a master’s degree dissertation written by Instituto Bernabeu biologist, Rafael Sellers. The research work entitled ‘Clinical outcomes in elective vitrification of embryos’, was managed by the Director of the Embryology Unit, Dr Jorge Ten.
The research is part of an extensive project submitted to the 1st National Congress of the Spanish Infertility and Sterility Society
Instituto Bernabeu was present at the 1st Spanish Sterility and Infertility Congress (SEISEGO) that was held within the framework of the Spanish Society of Gynaecology and Obstetrics (SEGO) event. Dr Rafael Bernabeu, Medical Director of the reproductive medicine clinic, is the society’s vice president and, as a prominent expert in the field, he opened the congress by moderating the first round table debate entitled ‘Updates in the basic analysis of the sterile partner’ along with Ana Belén Rodríguez.
Dr Andrea Bernabeu, a gynaecologist at Instituto Bernabeu, has assessed the most significant clinical data presented to the European Society of Human Reproduction and Embryology (ESHRE) congress and their importance.
Research is our lifeline. Each and every step is an accomplishment in prognosis for patients who have all the odds against them. In its October edition, Human Fertility, the prestigious scientific magazine mentioned research work undertaken exclusively by Instituto Bernabeu scientists that opens the doors to accelerating diagnosis in patients who have experienced implantation failure and recurrent pregnancy loss. It also helps prognosis with a view to providing early treatment for these patients.
The Rafael Bernabeu Welfare Foundation participated in the 4th edition of the National Rare Diseases Congress held in Ibi, a municipality of Alicante, on 30th and 31st October. It addressed the role of assisted reproduction treatment in avoiding transmission of genetic disorders. The congress aims to give people with rare diseases and experts in the field visibility, as well providing a forum for sharing information and analysis.
Dr Andrea Bernabeu, a gynaecologist at Instituto Bernabeu, participated in the ‘Family Medicine: the present, the past and the future’ symposium held on 26th October. It was organised within the framework of the 36th National Congress of Medicine Students (CNEM), 14th international edition, held in Alicante between 24th and 26th October. This collaboration falls within the framework of the Instituto Bernabeu and Miguel Hernández University (UMH) Chair of Reproductive and Community Medicine. One of the main objectives of the Chair is to ensure primary prevention of infertility and to provide general practitioners, gynaecologists and the general population with information on fertility.
Instituto Bernabeu actively participated in the workshops on reproductive medicine held in Castilla La Mancha, Albacete, on 19th and 20th October. The workshops were sponsored by Ferring. The aim was to share knowledge and latest updates. Lydia Luque, a gynaecologist and head of the clinic in Albacete, presented the event. It involved participation by doctors and biologists from 4 private clinics as well as an additional four specialist hospitals located in the Castilla La Mancha area that have human reproduction departments. “The aim was to review, refresh and share knowledge in order to progress, improve processes and improve management,” summarises Dr Luque.
Andrea Bernabeu, a gynaecologist at Instituto Bernabeu, coordinated the Personalisation and Individualisation of Reproductive Medicine Treatment workshop held in Valencia. Dr Bernabeu was part of a group of experts who participated in the 3rd edition of the Clinical Workshops on Reproductive Medicine. Specialists from different clinics shared their knowledge and updates based on scientific and clinical evidence. The aim was to improve approaches to patients.
The President of the Rafael Bernabeu Foundation and Medical Director of Instituto Bernabeu presented six scholarships for a total amount of 15,000 euros to students with excellent academic results and limited financial resources in order to help them continue with their studies. Within the framework of its commitment to society, the Rafael Bernabeu Foundation awarded scholarships worth 2,500 euros each to six medicine, nursing and biotechnology university students in order to cover the cost of fees and study material.
Instituto Bernabeu once again participated in the Congress of Pharmacy Students (CEFA). It held its 14th edition this year. Future pharmacists got to know the Instituto Bernabeu clinic headquarters in Alicante and gained first-hand knowledge of the role that pharmacists play in assisted reproduction treatment.
In addition to its patient treatment, healthcare and research work, teaching is part of Instituto Bernabeu’s DNA. This month, Instituto Bernabeu will participate in a postgraduate course run by Castilla La Mancha University for pelvic floor specialists. The course is aimed at physical medicine and rehabilitation experts in order to give them a comprehensive view of pelvic floor pathologies.
Instituto Bernabeu and the Faculty of Pharmacy at the University of Castilla La Mancha (UCLM) are organising the 3rd edition of the Master’s Course in Male Infertility that will be given at UCLM and at the reproductive medicine clinic. The aim is to broaden knowledge of reproductive medicine and the focus will be on the issues that men have when trying to conceive and the fact that this factor is equally as significant as infertility in women.
Dr Joaquín Llácer, an expert in ovarian reserve and Co-Director of Instituto Bernabeu, and Dr Ángela Llaneza, a gynaecologist and specialist in epidemiology at Instituto Bernabeu, participated in the 2nd Symposium on Controversies in Reproduction and Perinatal Medicine held on 27th and 28th September in the San Carlos Clinical Hospital in Madrid.
The Instituto Bernabeu is helping out once again this year in the University Master’s on Community Pharmacy Direction and Management & Optimization of Pharmaceutical Care organised by the Universidad Miguel Hernández (UMH). Doctor Andrea Bernabeu has taken part in this fourth edition that deals with aspects related to pregnancy and maternal-child health with theoretical and practical classes. In addition to the classrooms this year, there is a new showroom laboratory that has been fitted out like a real pharmacy so that the students can get some hands-on experience. The personal assistant of the Instituto Bernabeu, Tamara Ruiz.
Instituto Bernabeu and the University of Alicante (UA) will manage the 7th edition of the Master's Course in Reproductive Medicine for the 2018-2019 academic year. The aim is to provide experts from the world of health sciences with excellent and comprehensive training in the field of reproductive medicine.
Instituto Bernabeu has submitted a clinical study to the Spanish Fertility Society (SEF) congress that proposes ovarian sensitivity as a new marker in assisted reproduction.
What is the impact of the father’s age on his child’s health? This question was the backbone of the professional gathering that took place on 13th September in the Instituto Bernabeu auditorium, Alicante.
The new Instituto Bernabeu Group newsletter is now available, dedicated to our last reserach work accepted at FFER congress 2018.
Instituto Bernabeu has submitted three items of research work to the French Federation of Reproduction Studies (FFER) Congress that will be held in the French city of Lyon between 12th and 14th September. The event will bring together over 600 experts from all over the world who will exchange information on the latest updates in fertility and reproduction.
Research performed by Instituto Bernabeu has looked into whether fresh transfer or deferred transfer through cryopreservation followed by defrosting is the best strategy for carrying out pre-implantation genetic diagnosis for aneuploidies (PGT-A).
As a part of our continuous training programme, an intensive theoretical and practical seminar entitled ‘Advanced Workshop in Embryo Biopsy: Techniques and tips for usage’ will take place. The workshop is aimed at reproduction biologists who are specialised in micro-handling techniques.
During assisted reproduction treatment, conventional ovarian stimulation is performed over the first few days of the menstrual cycle. However, recent research shows that it can begin on any day of the menstrual cycle. The advantage is a decrease in the total time before treatment can begin. During the research, the oocyte retrieval results using the two strategies were similar.
Instituto Bernabeu has carried out research work with the aim of understanding if it is possible to predict the success of a cycle of egg donation by analysing two parameters: the number of mature donated oocytes obtained following ovarian stimulation and the quantity that are eventually fertilised.
Based on the positive results obtained, research performed by Instituto Bernabeu in Albacete entertains attempting ovarian stimulation in patients with low oocyte retrieval levels. The strategy is a step taken prior to egg donation.
With the incorporation of genetic techniques, it has been possible to identify a greater number of microorganisms that cannot be analysed with a normal microbiological culture and that make up the vaginal microbiome. A powerful tool to identify the microbiome are the massive sequencing techniques. The analysis of the microbiome is important since, among other things, in the field of reproductive medicine it is possible to detect if there is a microorganism that can facilitate or hinder the implantation of the embryo.
Since one of the parameters that enable us to measure assisted reproductive treatment efficiency is embryo morphology, its research is highly critical.
A study performed in the molecular biology and genetics laboratory at Instituto Bernabeu, IB Biotech, and submitted to the Spanish Fertility Society (SEF) congress has concluded that there is an increased risk of embryo abnormalities in chromosomal segments in young women.
Research carried out by Instituto Bernabeu has concluded that the use of heparin, an anticoagulant drug, improves prognosis in courses of in vitro fertilisation treatment (IVF) and ICSI (intracytoplasmic sperm injection) in patients who have experienced recurrent pregnancy loss or repeated implantation failure.
Instituto Bernabeu has submitted research work managed by Belén Lledó, Director of the clinic's Genetics Unit, to the Spanish Fertility Society (SEF) congress. The research involved analysis of mitochondrial DNA (mtDNA) in embryos and its link to the success of in vitro fertilisation treatment (IVF).
Instituto Bernabeu has submitted research work to the 32nd Spanish Fertility Society (SEF) National Congress held in Madrid. The aim of the study is to gain an understanding of drugs under conditions that differ from authorised use for courses of in vitro fertilisation (IVF) in patients with poor response, the frequency with which they are used in these cases and a review of the legal side to their administration. The research work is entitled: ‘Use of drugs under different conditions to those authorised within the framework of a course of in vitro fertilisation: a review of legal aspects and experience of use in patients with poor ovarian response.’
Parents' main aim in life is to ensure that their children are born healthy and that they, as parents, have the chance to ensure this happens. With this in mind, the Rafael Bernabeu Foundation makes its resources and research available so that people faced with health issues and also financial difficulties can try for children who are free of the illness they are carrying. The Rafael Bernabeu Foundation, Instituto Bernabeu's social wellness programme has, for many years, been offering preferential service when providing treatment for associations and social entities, including members of the Association in Support of the Mentally Ill of Alicante (Asociación Pro Discapacitados Psíquicos de Alicante, APSA).
‘Patients with poor ovarian response have a different distribution in the follicle-stimulating hormone (FSHR) genotype.’ This is the title of the research work that Instituto Bernabeu gynaecologist, Yasmina Ben-Aicha, presented at the Spanish Fertility Society (SEF) congress. The leading national infertility event’s scientific committee has accepted a total of 16 pieces of Instituto Bernabeu research work, 12 of which are oral presentations given by their lead authors.
The Instituto Bernabeu Group will once again attend the world's most significant reproductive medicine congress, both in terms of the work that is presented and in the number of specialists who attend.
Scientific research carried out by Instituto Bernabeu looked into the chances of a successful pregnancy using implanted embryos with chromosome mosaicism. It is a controversial issue because these embryos have a chromosomal abnormality in some cells and, until recently, these abnormalities were not detected. Thanks to current high-precision next-generation sequencing or NGS techniques and array-CGH during pre-implantation diagnosis for detecting aneuploidies, chromosomal abnormalities can be detected with precision in chromosome segments as well as in complete chromosomes.
Once again this year, Instituto Bernabeu was present at the 6th edition of the Mediterranean Forum, a national gathering organised by Merck under the title ‘Human Reproduction’ where gynaecologists learn about the latest in the field. The Director of the Reproduction and Genetics Guidance Unit at Instituto Bernabeu, Dr Andrea Bernabeu, was present at the event where exchanges on very latest in the field of reproductive medicine take place. Her presentation was on new forms of ovarian stimulation. The gynaecologist covered new approaches using personalised treatment, new protocols and new means of administering pharmaceutical drugs.
The group of clinic’s aim, as it travelled to France in order to hold an informative event, is to make Instituto Bernabeu known beyond our frontiers and open up new horizons to foreign patients who are unable to get pregnant naturally.
The 32nd edition of the Spanish Fertility Society (SEF) National Congress held in Madrid has handed the Instituto Bernabeu Group an award for its work entitled ‘Engagement of nursing staff in assisted reproduction treatment: what is patient opinion?’ under the communication promoted to presentation category. The award was given by the Scientific and Organisation Committee of the 7th edition of the National Nursing Congress that is held at the same time as SEF. The study in question was one of the 16 pieces of scientific research that Instituto Bernabeu presented at the leading national infertility congress. The clinic attends the congress every year and contributes work from its numerous fields of research.
The Medical Director at Instituto Bernabeu, Dr Rafael Bernabeu, recently participated in the Progress in Reproductive Medicine: Focus 2018 congress held in Italy. The event was held in Palermo, the Italian capital of science and life 2018, and it brought together leading international specialists in the field of reproductive medicine. His presentation was entitled ‘The potential of implanting mosaic embryos’ and it covered the next generation sequencing technique, the precision of which facilitates detection of embryos with mosaicism (they have cells with chromosomal abnormalities) and analysis of the chances that they have of implanting.
The medical codirector of Instituto Bernabeu, doctor Llácer, has participated in a masterclass in Greece attended by gynaecology professionals from across Europe. The expert on low ovarian reserve and director of the specific unit at Instituto Bernabeu spoke to his colleagues about the new personalized strategies for ovarian stimulation and subsequent handling in the obtaining of oocytes.
Rafael Bernabeu Charitable Foundation of Instituto Bernabeu, has celebrated the awards ceremony of the VIII Children's Drawing Contest on Motherhood. The reproductive medicine clinic Charitable Foundation, has presented the winners of the two categories, from 5 to 8 years and from 9 to 12 years with a diploma and a gift voucher of 300 euros, and with a diploma and a gift certificate of 100 euros to the two second places. The awards ceremony was held in the Sala Fnac Boulevard in Alicante and also another 16 children have received a diploma and a special gift.
As a part of our continuous training programme, an intensive theoretical and practical seminar entitled ‘Advanced Workshop in Embryo Biopsy: Techniques and tips for usage’ will take place. The workshop is aimed at reproduction biologists who are specialised in micro-handling techniques.
Instituto Bernabeu gynaecologist, Andrea Bernabeu, participated in the closing ceremony of the 3rd edition of the Community Pharmacy Management and Optimisation of Pharmaceutical Care Master's Degree at the Miguel Hernández University (UMH) in Elche, a course on which she has participated as a lecturer. The closing ceremony of the third edition and official inauguration of the fourth edition was held in the ADDA auditorium in Alicante. It coincided with the 8th edition of the National Congress of Community Pharmacists organised by SEFAC, the Spanish Society of Family and Community Pharmacies.
Instituto Bernabeu was present at the Italian Fertility, Sterility and Reproductive Medicine Society (SIFES) congress held in Riccione in Italy between 17th and 19th May. Paolo Cirillo, an Instituto Bernabeu gynaecologist, participated by giving two presentations at the gathering where experts in the field of infertility medicine meet.
Instituto Bernabeu took a total of 16 pieces of research work to the 32nd edition of the Spanish Fertility Society (SEF) National Congress. This is a significant quantity of work and, at the group of reproductive medicine clinics, research is an intrinsic part of its activity that is also put into practice during day-to-day provision of healthcare.
Eleven of the lines of research were presented as oral communications over the course of the event held between 16th and 18th May in Madrid’s convention centre where experts in reproductive medicine met.
The international congress entitled ‘A new approach to nursing in fertility’ held in the Instituto Bernabeu auditorium on 11th and 12th May brought together experts in infertility nursing from thirteen different countries. During the gathering, Dr Rafael Bernabeu, Medical Director at Instituto Bernabeu, highlighted the important role of nursing in reproductive medicine, a field in which Spain is a worldwide leader.
On 11th and 12th May, Instituto Bernabeu Alicante will organise a gathering of sixty experts in reproductive medicine nursing and auxiliary personnel with specialist skills in infertility. The most recent trends in this field will be covered in an international congress organised by Instituto Bernabeu and held in its headquarters in Alicante.
Juan Carlos Castillo, gynaecologist at the Instituto Bernabeu, has participated in a webinar (a talk given via internet in real time) offered by the English egg donation platform EggdonationFriends.com. The aim was to inform and respond to doubts sent by people around the world about infertility.
Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu, gave a speech at a conference held in Poland on treating patients with poor ovarian response and personalising courses of treatment.
‘IB International Workshop 2018: A new approach to nursing in fertility’ is the international congress due to be held on 11th and 12th May in the Instituto Bernabeu auditorium, Alicante. The event will bring together professionals from the field of nursing and experts in caring for reproductive medicine patients and, in doing so, share and explore knowledge that improves global care for these patients.