Kliniske Studier

Kliniske Studier
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A correct medical treatment must combine, together with dedicated care, the personalization of the process and in some cases, the application of R + D + I. At Instituto Bernabeu we are constantly carry out different lines of research to which, if they wish, our patients can join.

The relevance of endometrial compaction following exposure to progesterone in a replacement cycle for embryo transfer

The relevance of endometrial compaction following exposure to progesterone in a replacement cycle for embryo transfer

The subject being researched: Research into the potential significance of changes to the endometrium following exposure to progesterone for the development and posterior success of a pregnancy and whether or not these changes are driven by genetic predisposition. 

The aim: Comparison of reproduction results in preparation cycles for embryo transfer between patients whose endometrium decreases in the secretory phase prior to transfer and patients who maintain a stable or thicker endometrium. 

Scientific management: Dr Ll. Aparicio, Director of the Poor Ovarian Response Unit. Lead researcher: Dr Esperanza de la Torre, Gynaecologist specialising in assisted reproduction.

Start date: June 2021. Current situation: actively recruiting patients.

Location: Instituto Bernabeu in Alicante, Madrid, Albacete, Mallorca, Benidorm and Elche. 

More information: For more information click  here

Conventional folicular phase stimulation vs. Luteal phase stimulation in patients with suboptimal response. Randomized clinical trial. Subluteal trial

Conventional folicular phase stimulation vs. Luteal phase stimulation in patients with suboptimal response. Randomized clinical trial. Subluteal trial

What is studied: Suboptimal response to ovarian stimulation

Aim: study the difference in the number of eggs obtained by performing ovarian stimulation in follicular phase vs. Luteal phase in a population of patients with a prior suboptimal response

Scientific Director: Doctor Ll. Aparicio, Director Poor Ovarian Response Unit

Start: January 2020

Location: Instituto Bernabeu Alicante

More information: For more information click  here

For study details you can find them through the Ministery of Health

Prolutex in Frozen Embryo Transfer Cycles at the Blastocyst Stage (PROGEX) NCT03701490

Prolutex in Frozen Embryo Transfer Cycles at the Blastocyst Stage (PROGEX) NCT03701490

What is studied: It is the first clinical trial in the world to use Progesterone administered subcutaneously at a dose of 50 mg daily and compares it with standard vaginal administration.

Aim: We want to know the optimal treatment protocol that can improve the results through the administration route of the medication of patients who receive frozen embryos. 

Scientific Director: Doctor Ll. Aparicio, Director Poor Ovarian Response Unit

Start: March 2020

Location: Instituto Bernabeu Alicante

More information: For more information click here

For study details you can find them through the link

Efficacy of Urinary Vs Recombinant FSH in Oocyte Donors Based on Receptor N680S FSH Gene Polymorphism (Genodon Trial) (GENODON) NCT02625519

Efficacy of Urinary Vs Recombinant FSH in Oocyte Donors Based on Receptor N680S FSH Gene Polymorphism (Genodon Trial) (GENODON) NCT02625519

What is studied: It is the first clinical trial with a prospective and randomized design to assess the differences stimulation outcomes based on the gonadotropin used in patients with different genetic profiles.

Aim: We want to know the differences in the response to medication according to each woman’s genetic profile and the type of medication used.

Scientific Director: Doctor Ll. Aparicio, Director Poor Ovarian Response Unit

Current status: Recruitment phase

Location: Instituto Bernabeu Alicante

For study details you can find them through the link

Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles (LUTEAL Trial) (LUTEAL) NCT02625532

Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles (LUTEAL Trial) (LUTEAL) NCT02625532

What is studied: It is the first prospective and randomized clinical trial to assess the differences in the results of the stimulation depending on the moment of the cycle in which the administration of the treatment begins.

Aim: To know the possible differences regarding the number of eggs in patients with low response who start treatment in the follicular phase and luteal phase

Scientific Director: Doctor Ll. Aparicio, Director Poor Ovarian Response Unit

Current Status: Research ended 

Location: Instituto Bernabeu Alicante

For study details you can find them through the link

Conventional Ovarian Stimulation vs. Single Injection Stimulation of Corifollitropin Alfa in Oocyte Donor (TAIL) NCT03939403

Conventional Ovarian Stimulation vs. Single Injection Stimulation of Corifollitropin Alfa in Oocyte Donor (TAIL) NCT03939403

What is studied Explore the possibility of completing all ovarian stimulation with just one injection of medication.

Aim: Confirm the possibility of administering all the stimulatory action with a single injection of Corifolitropin alfa without the subsequent administration of more doses in patients with a normal response to stimulation.

Scientific Director: Doctor Ll. Aparicio, Director Poor Ovarian Response Unit

Current Status: Actively recruiting patients

Fecha prevista finalización: December 2020

Location Instituto Bernabeu Alicante

For study details you can find them through the link

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