Optimizes and improves cycles for egg donors, oncology patients, women with low reserve, immature oocyte syndrome and empty follicle syndrome
The international medical journal Upsala Journal of Medical Sciences has just published a research paper led by Instituto Bernabeu entitled "Gonadotropin-releasing hormone agonist ovulation trigger — beyond OHSS prevention". It was developed by Instituto Bernabeu gynecologist, expert in ovarian stimulation, Dr. Juan Carlos Castillo with the participation of Thor Haahr, María Martínez-Moya and Peter Humaidan. The goal of this review is to present the advantages of the gonadotropin-releasing hormone agonist (GnRHa) trigger in ovarian stimulation during reproductive medicine treatment. It highlights that its role goes beyond the prevention of ovarian hyperstimulation syndrome (OHSS).
On Thursday the 21st of May, the doctors of Instituto Bernabeu, Dr. Joaquin Llácer and Dr. Juan Carlos Castillo, have been invited to give a webinar to the doctors of the Peruvian Society of Fertility.
Our Pregnancy and Childbirth Guarantee Program was the first to emerge in Europe, now 6 years ago. It was born with the vocation of providing certainty in success and releasing patients from worries; patients are offered full coverage of all medical assistance they may require in their reproductive treatment until the pregnancy is achieved, eliminating uncertainty until the birth of their child, or they would receive a full reimbursement.
Instituto Bernabeu’s Head Doctor, Dr Rafael Bernabeu, will conduct this Wednesday 29th of April the webinar Covid-19: How and when can I start or retake my fertility treatment? Dr Bernabeu will answer live through YouTube Live, all questions related to this pandemic and how affects fertility treatments from 10am and from 11am to all non-Spanish patients in English.
The new Instituto Bernabeu Group newsletter is now available. 27th OF APRIL Resume the reproductive medicine activity.
The Fertility Image group of the Spanish Fertility Society (SEF) coordinated by Instituto Bernabeu doctor Belén Moliner has organized a webinar for this Wednesday, April 22, to show updates on ultrasound technology.
The difficult situation caused by the Covid-19 pandemic, which affects both men and women in the andrological, gynecological, obstetric and reproductive spheres, is generating a multitude of information, at times confusing, that requires analysis and study to manage it properly.
In these extraordinary times in which we are living, in isolation, we want to be even closer to our patients so they know we remain at their disposal. If you are not yet a patient, but you would like to get to know us, you can also send us your questions.
We know that there are things that cannot wait, and distance and isolation should not be an obstacle. We offer you online fertility consultation, hand in hand with our specialists in the most advanced reproductive medicine. If it is not possible to see each other in person, through personalized attention via videoconference, you can carry out your first fertility appointment online or prepare the next steps of your case if you are already a patient. New technologies bring us closer and help us move forward with our personal goals.
Sometimes, gynecological health requirements or pregnancy needs do not know of confinements and cannot wait, that is why we have especially enabled a few hours to be able to attend to your needs in person. You can carry out gynecological, fertility and pregnancy follow up consultations, as well as diagnostic or laboratory tests that may be required for a correct diagnosis.
Given the seriousness of the situation that our country and its medical professionals are facing to combat the pandemic caused by covid-19, all the clinics of Instituto Bernabeu have given to the health authorities all their medical and surgical equipment that may be necessary to combat coronavirus.
The new Instituto Bernabeu Group newsletter is now available. Coronavirus COVID-19. Uptading regarding our activity status.
Instituto Bernabeu and the role of its genetics and molecular biology laboratory have been used to instruct biotechnology students at Miguel Hernández University (UMH) about the day-to-day demands of their future profession. The talk took place within the framework of the 8th Employment in Biotechnology event, to which the clinic was invited.
Instituto Bernabeu played a leading clinic role in a scientific gathering of assisted reproduction experts organised by Merck in Valencia. Dr Andrea Bernabeu, Co-Director of Instituto Bernabeu and Coordinator of the Genetics and Reproduction Assessment Unit; Dr Jorge Ten, Director of the Embryology Unit; and Dr Juan Carlos Castillo, a gynaecologist and expert in ovarian hyperstimulation syndrome at Instituto Bernabeu, all attended the event.
Ongoing training and participation in congresses is part of the day-to-day work routine at Instituto Bernabeu. One such example this month was the first edition of the Assisted Reproduction Event held in Toledo (Spain) on 21st and 22nd February. Mónica Aparicio, an embryologist at Instituto Bernabeu in Madrid, participated in the gathering of experts where male factor and DNA fragmentation issues were addressed. Her intervention covered the techniques that are performed at the clinic.
At the third edition of the symposium on controversial issues in the field of reproductive and perinatal medicine, Dr Llaneza highlights the role of anti-Müllerian hormone when personalising stimulation
Instituto Bernabeu participated in the third edition of the symposium on controversial issues in the field of reproductive and perinatal medicine which was held in Madrid in late January. Dr Ángela Llaneza, a specialist in reproductive medicine at the clinic in Madrid, participated in the event by giving a lecture entitled ‘Anti-Müllerian Hormone (AMH) and reproduction guidance’.
The Manager of the Embryology Unit at Instituto Bernabeu, Dr Jorge Ten, has given a lecture on the Master’s Course in Human Reproduction organised by Complutense University in Madrid (UCM) and the Spanish Fertility Society (SEF). The doctor has been actively involved in course for over a decade. Dr Ten addressed the issue of oocyte vitrification. Instituto Bernabeu is a groundbreaking clinic in this field with over fifteen years of experience of vitrification of both gametes and embryos. Practices such as these need to be performed under a robust vitrification programme and by experienced embryologists. The Master's Course, in which Instituto Bernabeu plays an active role, trains students in highly specialised reproductive medicine skills and updates their scientific knowledge.
The Instituto Bernabeu Group has obtained the ISO 14001:2015 Environmental Management System Certificate in all its clinics; Alicante, Madrid, Palma de Mallorca, Albacete, Cartagena, Elche and Benidorm.
Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu and expert in poor ovarian reserve; Dr Juan Carlos Castillo, a specialist in ovarian stimulation; and Cristina García-Ajofrín, a gynaecologist at IB in Madrid and an expert in uterine causes of infertility, have given three master classes to students on the University of Alicante and Instituto Bernabeu Master's degree in Reproductive Medicine.
A woman’s ovarian reserve is the number of viable oocytes that she has in her ovaries at any given time. This figure conditions the quantity of ova that can be retrieved during in vitro fertilisation treatment. As a woman ages, her ovarian reserve decreases and this is why the Medical Director at Instituto Bernabeu, Dr Rafael Bernabeu, has emphasised the importance of this factor and encouraged both experts in the field and patients to be keenly aware of this before it is too late.
Instituto Bernabeu participated in a gathering of experts at the ‘Endometriosis and infertility: the extent of the problem’ ESHRE Campus held in Milan on 23rd and 24th January 2020. The scientific event, organised by the European Society of Human Reproduction and Embryology’s endometriosis and endometrial disorders work group, selected research work carried out by Instituto Bernabeu as a candidate for the best poster award. Dr Belén Moliner, the clinic's expert in endometriosis, attended the meeting in order to answer questions about the research work: ‘The inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure with endometriosis and without it.’
Instituto Bernabeu researchers have studied the impact of the male factor on embryo mosaicism or cases of embryos with some normal cells and some chromosomally abnormal cells. It is one of the reasons for implantation failure but the factors that cause it remain unclear. The aim of the study was to assess which male factors could have an impact on embryo mosaicism rates.
The Embryology and Reproductive Medicine Units at Instituto Bernabeu are leading research aimed at determining if a reasonable number of good quality blastocysts (embryos on days 5 to 6 or development prior to implantation) can be retrieved following culture and observation of oocytes that have not fertilised correctly. In in vitro fertilisation laboratories, around 20% of inseminated oocytes suffer fertilisation failure and 3% of oocytes fertilise abnormally.
Instituto Bernabeu has undertaken a research project that aims to analyse if using probiotics could improve pregnancy rates in assisted reproduction treatment. To this end, the clinic has performed a study involving a group of patients with a recurrent implantation failure (RIF) diagnosis, plus another group of patients with no such diagnosis.
Instituto Bernabeu has participated in a professional event for general health and reproductive medicine specialists. The clinic addressed the procedures it adheres to for egg and sperm donation, in addition to means of achieving improved results. The congress was entitled ‘Means of diagnostic and therapeutic healthcare in assisted reproduction procedures and synergies between specialists in the field.’ Instituto Bernabeu addressed the requirements for and access to heterologous artificial insemination through egg donation, sperm donation and embryo adoption.
The genetics laboratory at Instituto Bernabeu is using next-generation sequencing to find out what is behind unknown causes of sterility. In 2020, Instituto Bernabeu will continue with work on the research into this subject that it started in 2018. Instituto Bernabeu points out that next-generation sequencing can be used to work out what causes sterility when other conventional clinical diagnoses techniques cannot.
Instituto Bernabeu research aimed to determine if any ovarian stimulation factors can be linked to oocyte morphology and to the type of membrane breakage when intracytoplasmic spermatozoa injection (ICSI) is performed. This assisted reproduction technique is routinely used in in vitro fertilisation (IVF) laboratories. It has the huge advantage of providing a helping hand when male patients suffer from severe male factors and it stops sperm counts from being a limitation. However, the main disadvantage is that the results depend to a large degree on the operator performing the technique. Although specialists are currently able to perform the process securely, there are some variations in the results that they obtain. Differences between oocytes in ICSI are observed even when an egg donation programme is used.
The new Instituto Bernabeu Group newsletter is now available. Microbiome analysis in patients with embryo implantation failure.
Instituto Bernabeu in Cartagena is organising a scientific event to address progress in the treatment of uterine fibroids. The event will be held on Friday, 31st January in the graduation room at the Polytechnic University in Cartagena. This is just one of many scientific events that the clinic regularly organises at its Cartagena branch. The purpose of the events is to improve knowledge of reproductive health.
Instituto Bernabeu is set to employ a new technique that helps women under 35 years of age to have children with their own ova. These women are otherwise compelled to turn to egg donation
Instituto Bernabeu's social welfare entity invests over €123,000 in courses of treatment for patients who have limited financial resources. This is over 70% of the €176,000 total spend. It donates €33,500 to NGOs, €14,200 to science and research and €10,000 to student scholarships.
Instituto Bernabeu’s participation in events held in Portugal on 4th and 5th December focused on poor responders and new strategies to help women achieve a pregnancy.
Does the number of oocytes obtained following ovarian puncture have an impact on embryo quality? This is the question that a team of researchers from the Embryology Departments at Instituto Bernabeu in Alicante and Albacete and the genetics laboratory at Biotech asked themselves as they proceeded to study the results obtained in almost 400 cycles of in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). The research work was presented in poster format at the Association for the Study of Reproduction Biology (ASEBIR) Congress, a gathering attended by leading global experts. The research was based on the relationship between the number of oocytes obtained following ovarian puncture and the results of IVF treatment.
Dr Rafael Bernabeu, Medical Director at Instituto Bernabeu, gave a speech within the framework of the ‘Review and updated handling of recurrent pregnancy loss’ course held in Madrid. The event was organised by the Spanish Society of Gynaecology and Obstetrics (SEGO).
A team of researchers from the Embryology and Reproductive Medicine Units at Instituto Bernabeu in Madrid and Alicante have completed a study of the factors that may have the greatest impact on embryo transfer rates following a cycle of assisted reproduction. The research work was presented at the Association for the Study of Reproduction Biology (ASEBIR) Congress held in late October in Cáceres.
The aim of research work performed by the Genetics and Molecular Biology Department at Instituto Bernabeu IBBiotech was to determine if there is a relationship between the ovarian stimulation process in cycles of in vitro fertilisation (IVF) and the aneuploidy and mosaicism rate in embryos. The conclusions were presented at the Association for the Study of Reproduction Biology (ASEBIR) Congress held in October in Cáceres.
Instituto Bernabeu gave an oral communication about oocyte vitrification at the Association for the Study of Reproduction Biology (ASEBIR) Congress held in Cáceres in October. Freezing is common practice during in vitro fertilisation (IVF) treatment because it increases the available number of blastocysts for analysis.
Instituto Bernabeu’s strive for excellence is clearly marked out in a meticulous work method and implementation of the most demanding healthcare and process quality controls with the aim of always achieving excellent results. The healthcare that patients are given is endorsed by certifications and accreditations awarded to the clinic by independent entities. Instituto Bernabeu Group has recently been awarded the QH* accreditation. It entails not only a renewal of the Quality Healthcare (QH) certification, but also an additional, higher level that has been driven by the ‘increase in the validity of certain certifications’, as highlighted by the Institute for Development and Integration of Health (IDIS), the accrediting organism.
Instituto Bernabeu gave an oral communication at the European Society of Human Reproduction and Embryology (ESHRE) Congress entitled ‘The luteal phase of double ovarian stimulation treatment (DuoStim) provides higher oocyte and blastocyst yield in unselected infertile patients: a retrospective, same-patient, cohort study.’ This study is included in the articles that Merck has featured in its specialist journal focussing on fitting publications that is released following the scientific gathering focussing on fitting publications.
Instituto Bernabeu attended the Association for the Study of Reproduction Biology (ASEBIR) Congress held in Cáceres and presented a study about the effect that segmental chromosomal aneuploidies have on the embryo.
Once again this year, Instituto Bernabeu attended the Association for the Study of Reproduction Biology (ASEBIR) Congress. It was held in Cáceres from 23rd to 25th October 2019. Nine items of research work performed by the Embryology Unit and the Molecular Biology and Genetics Department were presented at the national congress. It is the most significant congress of its kind in the field of reproduction biology.
Instituto Bernabeu attended the World of Microbiome Pregnancy, Birth and Infancy congress held in Milan, Italy from 31st October to 2nd November. Dr Belén Lledó, Scientific Director of IBBiotech presented Instituto Bernabeu’s pioneering research into the impact of the vaginal microbiome on the results of assisted reproduction treatment.
Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu, moderated the Endometrial Receptivity Workshop held within the framework of the 4th Clinical Workshops on Reproduction Medicine organised by Ferring and held in Valencia on 8th and 9th November.
Instituto Bernabeu has submitted a pilot study involving ova donors to the European Society of Human Reproduction and Embryology (ESHRE). It researches differences in results when conventional ovarian stimulation protocols are applied in comparison with new, no fixed time stimulation protocols that do not take the stage of the menstrual cycle into account. The research entailed an analysis of ova donation cycles which was performed over ten months. It compared stimulation beginning on days 1 to 3 with ovarian stimulation that had no fixed time from day 4 onwards.
The Rafael Bernabeu Social Welfare Foundation has published the results of the 2018-2019 scholarships awards. The scholarships provide Medicine, Nursing, Biology and Biotechnology students in Spain with financial support in order boost their studies. On this occasion, further to assessment of all the applications that were received, the Awards Committee chose to award four students the scholarships worth a total of 10,000 euros.
Instituto Bernabeu participated in the 75th edition of the American Society for Reproductive Medicine (ASRM) congress held from 12th to 16th October in Philadelphia. It is one of the leading congresses in the world both in terms of the number of participants and in terms of the quality of the work that is presented there. Dr Joaquín Llácer, Medical Co-Director of Instituto Bernabeu, was the clinic representative at the global gathering of experts attended by 9,300 people from 94 countries. It is a not-to-be-missed event in the field.
The recent international congress Meeting The Experts provided relevant reviews and information on the latest scientific advances in the treatment of reproductive problems. We were able to interview all the speakers that clarified these aspects. Here are all the videos of the interviews to broaden and complete their contribution.
Dr Rafael Bernabeu, Medical Director of Instituto Bernabeu, has addressed medical and healthcare aspects of cross-border reproductive medicine in a gathering of experts in law organised by the University of Alicante (UA). The seminar, entitled ‘Multi-disciplinary outlooks for studying healthcare in cross-border reproduction’, was held on 23rd September and gynaecologist Dr Bernabeu delivered the specialist’s point of view on the subject. The event was organised by the Department of Civil Law and it was attended by full professors and associate professors in Sociology and Civil Law.