next-generation sequencing

Can a patient know and choose their future child’s gender before embryo transfer?

It is possible to determine the gender of a future baby (embryo) before transfer takes place. In fact, this strategy has been used for many years in order to avoid the transmission of sex chromosome hereditary diseases (pre-implantation genetic diagnosis or PGD).
When the technique was in its early days, embryo analysis was carried out on day 3 of embryo development. Nowadays, it is carried out between days 5 and 7 of development (blastocyst stage). The analysis provides a simultaneous understanding of all the chromosomes in the embryo, meaning that transmission of chromosomal abnormalities can be completely eliminated. The technique has a 98% success rate. […]

2018-01-03T10:07:02+02:005 de January de 2018|0 Comments

Should embryos with chromosomal mosaicism be rejected?

When good quality embryos do not implant correctly or lead to pregnancy loss, in vitro fertilisation (IVF) does not provide us with the results we had hoped for. This is often because the embryo is a carrier of abnormal chromosomes. Fortunately, in our clinic, we have access to the very latest in embryo chromosome diagnosis techniques such as array CGH and next generation sequencing (NGS). We can use this technology to detect abnormalities in the embryo that will cause pregnancy loss or that will lead to the birth of a child with chromosomal abnormalities such as Down’s Syndrome, also known as trisomy 21. As such, we can use these techniques to select and transfer the embryos with the greatest chance of leading to the birth of healthy child. […]

2018-03-26T17:47:29+02:0025 de August de 2017|0 Comments

Genetic compatibility in couples

When faced with fertility issues, many people believe that this is often due to the couple’s incompatibility. The reason behind this inability to fall pregnant is often unknown and quite simply a mystery due to some form of irresolvable  ‘genetic issue’. When faced with such circumstances, we can but give in and accept it and, as with all popular beliefs, there is some truth in it.
It’s estimated that around 20% of reproduction issues are down to genetics. In fact, many of the tests carried out as part of patient fertility analyses in our clinic, aim to determine if there is a genetic issue behind the couple’s difficulties falling pregnant. […]

2019-04-10T09:19:54+02:007 de October de 2016|0 Comments

The 600 recessive disorders detected by the Genetic Compatibility Test (GCT)

Nowadays, all couples who wish to avoid passing on genetic disorders to their children can choose to do so through a Genetic Compatibility Test (GCT), also known as Prenatal Recessive Disorder Screening.
The Instituto Bernabeu GCT is a groundbreaking analysis that uses next-generation DNA sequencing (NGS) through which we study 555 genetic mutations which cause over 600 autosomal recessive disorders in a simple blood sample.

Please see below the list of mutations analysed by the GCT we do at INSTITUTO BERNABEU:

The 600 recessive disorders detected by the Genetic Compatibility Test (GCT)
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2018-04-17T17:25:29+02:0025 de May de 2016|0 Comments
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