CCS (Comprehensive Chromosome Screening) and unexplained sterility

Any couple that turns to a fertility clinic undergoes a number of tests in order to diagnose the fertility issue that is making natural conception impossible. It is estimated that, at the end of the process, 1 in 4 couples are provided with no apparent reason for the reproduction issue. In these couples, no significant findings came up in the diagnostic tests carried out both on the male and the female partner.
Circumstances such as these generate a great deal of uneasiness and doubts in couples because, with no known reason for their infertility, they feel as if they were in no man’s land. […]

2017-10-04T13:53:00+00:006 de October de 2017|0 Comments

What impact do toxic substances have on fertility?

A wide variety of toxic substances have a damaging effect on fertility.
On the one hand, we have the toxic substances over which we have a direct control in terms of use (tobacco, alcohol, etc.) and, on the other, the toxic substances that we cannot, as individuals, control (environmental factors).
Toxic habits
With reference to the toxic substances that we can control, one of the most well-known and studied of them all, and that is known to clearly have an impact on human reproduction, is tobacco. There are over 4,000 substances in tobacco that are considered toxic. These include cadmium, nicotine and polycyclic hydrocarbons. […]

2017-09-27T11:17:42+00:0029 de September de 2017|0 Comments

How can the best spermatozoon for fertilising an egg be selected?

Selection of the spermatozoon capable of fertilising an egg and generating a viable embryo is a subject that has been covered in a great number of studies aiming to provide this question with an answer.
Although assisted reproduction techniques have been used for dealing with fertility issues for many years, there is still room for improvement in terms of the results obtained. First of all, we need to fully determine the role of the spermatozoon because it tends to be thought of simply as the transporter of the father’s genetic material with no impact on later development. This idea has already been turned on its head and sperm does not only play a role in the fertilisation process. An abnormal spermatozoon can give rise to abnormal embryos and can even influence implantation failure. […]

2017-09-01T14:27:10+00:001 de September de 2017|0 Comments

New examination aimed at testing couples with recurrent implantation failure

Instituto Bernabeu focusses on providing personalised solutions, particularly in cases of patients with a difficult reproductive prognosis (low ovarian reserve and recurrent implantation failure (RIF)).
Carrying out a number of empirical tests and treatments has, on occasions, been put forward as an option in the case of patients suffering from recurrent implantation failure. The latter have proven to be of questionable efficacy and the former have proven to be of limited or no use.
One of the proposed strategies for patients with recurrent implantation failure (RIF) that is providing many of these cases with solutions, is IVF (in vitro fertilisation) with elective freezing and biopsies on all embryos so that the frozen embryos can later be transferred during a natural cycle. In other words, without any hormone treatment.
It is possible to recreate the conditions under which transfer takes place during treatment of this kind by carrying out a mock cycle and evaluating a series of parameters that can influence transfer success. […]

2017-07-03T13:35:43+00:0030 de June de 2017|0 Comments

Could it be implantation failure why I don’t get pregnant? Diagnosis in one day.

Achieving pregnancy when pregnancy does not come is one of the challenges the medical team at Instituto Bernabeu faces every day. One of the most important challenges of female infertility is implantation failure. The embryo does not get to nest in the maternal uterus or it does but the woman undergoes an early miscarriage, which produces a great frustration. The couple should put themselves as soon as possible in the hands of the specialist and not leave to chance or wait the passage of time to solve a situation that requires a personalized study.
Instituto Bernabeu Medical Director, Dr Rafael Bernabeu explains: “The causes of implantation failure are multiple, but contrary to the general opinion, patients believe they are causing the problem when, in fact, to a great extent the problem is embryonic”. Therefore, the medical centre global benchmark in reproductive medicine develops a study of the three patients: “The mother, the father and the embryo.” Twenty-five percent of embryo implantation failures cases, “do not have a clear cause” and in many cases, there is a combination of factors that can be combined, warns Dr Rafael Bernabeu. Not only are environmental and immunological factors, they are also due to the intake of certain foods and even to the cosmetics used. “We are exposed to tens of thousands of chemical substances and many generate disorders and among them may be the cause of repeated miscarriage and implantation failure,” says Dr Bernabeu. […]

2017-01-27T15:58:14+00:0027 de January de 2017|0 Comments

What information does a FISH procedure on spermatozoa provide us with?

When a fertility analysis in the male partner is limited to a seminogram or spermiogram, we only get a partial view of semen quality. A seminogram only provides us with information on the number and characteristics of sperm in the ejaculate (mobility, morphology…). It does not, however, tell us anything about other aspects such as sperm DNA integrity […]

2017-01-20T14:03:48+00:0020 de January de 2017|0 Comments

Progesterone and its role in reproduction

What is progesterone? Just a simple look at the word itself gives us an idea of what its functions are. PROGESTERONE: the hormone which facilitates pregnancy. This is a good point from which to start out.
Progesterone plays an essential role in pregnancy and it has many and varied effects. It is a natural substance which is secreted from the ovaries following ovulation and continues throughout the second half of the menstrual cycle. Progesterone ensures that a woman’s uterus is receptive and, when production is insufficient, the embryo does not implant correctly or runs a high risk of leading to a miscarriage. It also relaxes the muscles in the uterus, making it better suited for the early days of pregnancy. […]

2016-11-17T18:41:53+00:0018 de November de 2016|0 Comments

Implantation failure and repeated miscarriage. Treatment options

Successfully treating implantation failure and recurrent pregnancy loss is undoubtedly a challenge for doctors and for patients.

It is an area on which we continuously focus research at Instituto Bernabeu and, whilst we are far from finding a solution to all problems, the number of couples we are able to successfully treat is forever increasing.

An approach which does not take all 3 parties into account – the female, the male and the embryo – is incomplete. When evaluation only takes the couple into account, the reason behind the issue is only determined in under 20% of all cases. […]

2016-11-15T18:25:49+00:0015 de November de 2016|0 Comments

The endometrial receptivity array (ERA) test

Embryo implantation is the least well known phase of reproduction within the field of reproductive medicine. This fact is of special relevance if we also take into account that the human embryo is not very efficient when compared to other closely-related species in the evolution timeline.
We currently know that pregnancy is based upon three basic pillars: the embryo, the endometrium and the tolerance of the mother’s immune system. Not only is it essential that all three function correctly, but there needs to be optimum interaction between them. We have already covered the role of the embryo and the immune system in detail. Therefore, we will now concentrate on the endometrium and, more specifically, on studying endometrial receptivity. […]

2017-10-02T14:50:28+00:009 de September de 2016|0 Comments

Diagnostic hysteroscopy and endometrial scratching

We consider an evaluation of the uterine cavity and a check to ensure normal structure in the tissue that lines it (the endometrium) to be a standard part of any implantation failure study. In order to carry out such a study, the most appropriate diagnosis consists of a diagnostic hysteroscopy and an endometrial biopsy.
A hysteroscopy is an endoscopy of the uterus. In other words, direct inspection of the uterine cavity using an optical system. It’s a simple test and practically pain free in most cases. Therefore, it is generally carried out during an appointment with minimal patient preparation and no impact on her daily life. […]

2017-10-02T14:51:13+00:003 de June de 2016|0 Comments
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