FISH

CCS (Comprehensive Chromosome Screening) and unexplained sterility

Any couple that turns to a fertility clinic undergoes a number of tests in order to diagnose the fertility issue that is making natural conception impossible. It is estimated that, at the end of the process, 1 in 4 couples are provided with no apparent reason for the reproduction issue. In these couples, no significant findings came up in the diagnostic tests carried out both on the male and the female partner.
Circumstances such as these generate a great deal of uneasiness and doubts in couples because, with no known reason for their infertility, they feel as if they were in no man’s land. […]

2018-03-28T10:55:25+02:006 de October de 2017|0 Comments

What information does a FISH procedure on spermatozoa provide us with?

When a fertility analysis in the male partner is limited to a seminogram or spermiogram, we only get a partial view of semen quality. A seminogram only provides us with information on the number and characteristics of sperm in the ejaculate (mobility, morphology…). It does not, however, tell us anything about other aspects such as sperm DNA integrity […]

2018-03-26T17:56:49+02:0020 de January de 2017|0 Comments

Recurrent pregnancy loss: an issue that does have a solution

Clearly one of the most difficult situations a couple trying for children may have to face is pregnancy loss. Suffering is even greater when, prior to this, the couple has gone through fertility treatment such as in vitro fertilisation, insemination or egg donation.
Pregnancy loss is not always the result of an illness or underlying abnormality. It can be the response nature provides in order to block the development of an abnormal embryo. In fact, when the tissue from the pregnancy loss is examined, a large number of chromosomal abnormalities can be detected. […]

2016-10-13T12:23:48+02:008 de April de 2016|0 Comments

State of the art technology in preimplantation embryo diagnosis: Array-CGH

Preimplantation Genetic Diagnosis (PGD) is the study of chromosomal and genetic abnormalities in embryos before they are transferred to the mother’s uterus by an In Vitro Fertilisation (IVF) technique. It seeks to ensure healthy offspring and stop transmission of a given disease. […]

2016-08-04T13:13:58+02:0011 de March de 2016|0 Comments

Comprehensive Chromosomal Screening (PGS/PGT-A/CCS): More reliable and less damaging for embryos

The necessary information for an adequate development of human beings is contained in some “books” called genes; they are written in an “ink” called DNA. Our total number of genes is found in the 46 chromosomes that we inherit from our parents, and it should have no excesses or deficiencies, since these could cause serious diseases and malformations, and even put our life in danger.
Human embryos have a high rate of chromosomal alterations, especially in the case of couples with fertility problems, such as recurrent miscarriages and implantation failures. For this reason, when we are in the In Vitro Fertilisation (IVF) laboratory with a couple’s embryos, we already know it is very likely that many of them are chromosomally abnormal.
Only embryos with no excesses or deficiencies in their DNA have the capacity to produce a healthy newborn. Therefore, by identifying and selecting an embryo with a full chromosome count, we manage to guarantee that the embryo has maximum capacity to produce a healthy child. […]

2018-05-31T14:11:03+02:0024 de December de 2015|0 Comments

PGD, PGS, CCS and PGT-A: are they all one and the same?

PGD or pre-implantation genetic diagnosis consists of a set of techniques used on the embryo prior to transfer to the mother’s uterus with the aim of studying any possible chromosomal and/or genetic abnormalities. Its purpose is to ensure that children are born healthy and put an end to the transmission of a given condition to offspring.
Huge steps forward in the analysis of embryo abnormalities have been made in the 21st century. The range of options in diagnosis as well as the reliability of the techniques have turned something that was a pipe dream only a few years ago into a reality. These techniques are now routine and Instituto Bernabeu is a worldwide leading entity in providing its patients with the latest developments in embryo genetic diagnosis. […]

2018-04-11T11:10:35+02:006 de November de 2015|0 Comments

Genetic approach to embryo implantation failure and repeated miscarriage

Couples that don’t achieve pregnancy after in vitro fertilization treatments and those who lose their pregnancy in early stages require a multidisciplinary approach in order to diagnose and treat their reproductive problem.
 
From a genetic point of view, these patients are more likely to produce embryos with chromosomal abnormalities. To improve these couples’ pregnancy rates, the preimplantational genetic diagnosis (PGD) can be applied. In these cases, the goal is to select the embryos with the highest capacity of resulting in an ongoing pregnancy thanks to the fact that the PGD allows us to identify the number of chromosomes in the embryo. Only embryos with the correct number of chromosomes can lead to a healthy child, others will arrest in their development or will lead to a miscarriage. […]

2018-03-27T19:29:38+02:0016 de December de 2013|0 Comments

Array-CGH: Discovering the miracles of the embryo. Comprehensive Chromosome Screening (PGS/PGT-A/CCS)

New technologies are making remarkable progress in the diagnosis of fertility. The latest development that has been incorporated into the range of diagnostic techniques is called array-CGH.
This new genetic test allows us to analyze our cells’ DNA to limits that years ago we would have considered pure science fiction.
The human genome is made up of 46 chromosomes: 23 from the father and 23 from the mother. All of our organism’s genetic information is stored in these chromosomes. The excess or defect of any chromosome region may be responsible for certain diseases or fertility problems, such as implantation failure or recurrent miscarriages. […]

2018-03-26T18:36:18+02:0010 de April de 2013|1 Comment

Spermiogramme and Advanced Semen Studies (FISH AND TUNEL)

A seminogramme or spermiogramme is one of the basic studies performed on men to determine the sperm quality. Sperm is analysed from both a macroscopic and microscopic viewpoint. The most relevant parameters of the study are threefold:
–          Sperm count
–          Sperm motility
–          Sperm morphology
[…]

2016-09-22T12:29:19+02:0026 de April de 2011|4 Comments
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