endometrium

The link between thrombophilia and recurrent implantation failure

The percentage of pregnancies achieved following assisted reproduction treatment has progressively increased over the years but we still have a long way to go before we achieve optimum results. This is why alternative treatment options that have not already been attempted are taken into account when several courses of treatment have not given a positive result.

It has been […]

2019-03-22T09:45:54+02:0022 de March de 2019|0 Comments

What role does the immune system play in fertility?

From an immunological point of view, pregnancy is a unique set of circumstances because a woman’s body has to ‘withstand something that is foreign to it’. The mother has to carry the embryo and, in order to do so, her immune system needs to accept co-existence with cells that are at least half foreign in origin. Using a […]

2019-03-15T10:09:00+02:0015 de March de 2019|1 Comment

What is the corpus luteum?

After ovulation, follicles transform into the corpus luteum or ‘yellow body’. Corpus luteum development depends on the luteinising hormone (LH) surge before ovulation and on the number of receptors for this gonadotropin in the granulosa cells and in the theca cells.  Both types of cells go through significant changes in structure and composition and this turns the walls of the corpus […]

2019-03-04T12:41:29+02:0022 de February de 2019|0 Comments

What is oestradiol? What is this sex hormone’s role?

Hormones are messengers that are present in all multicellular organisms – be they animal or plant organisms – that coordinate the functions of each part of that organism.
The sex hormones par excellence are oestradiol in females and testosterone in males. However, the adrenal glands in men and women produce both hormones and they are both necessary for normal development of the two sexes. […]

2018-08-08T14:20:13+02:0010 de August de 2018|0 Comments

The advantages and disadvantages of transferring embryos during a natural or artificial cycle

Embryo transfer to the uterus is the pinnacle of all courses of assisted reproduction treatment. It cannot be left to chance. The endometrium needs to be receptive and facilitate embryo embedding.
The endometrium can be prepared with the aid of drugs (oestrogens) to simulate natural uterine behaviour – a substituted or artificial cycle – or transfer can be carried out whenever biologically most appropriate following ovulation – transfer during a natural cycle. […]

2018-03-28T12:54:41+02:0029 de March de 2018|0 Comments

Embryo transfer on day 4 – why not?

In most laboratories, embryo transfer traditionally takes place on day 2 to 3 of culture, or during blastocyst stage, whilst embryo transfer on day 4 is an alternative that has not commonly been adopted into laboratory practice.
When compared with embryo transfer during early stages, blastocyst transfer is generally accepted as superior. This is mainly for reasons of improved synchronisation between the embryo and the endometrium and more objective embryo selection once the genome has been activated. It means that a smaller number of embryos can be transferred, thus avoiding the risk of a multiple pregnancy. […]

2018-03-08T12:52:29+02:009 de March de 2018|0 Comments

What is a progesterone deficit? Administration and side effects

Progesterone is one of the most important hormones in a woman’s metabolism and fertility. It is produced by the ovaries following ovulation during a normal menstrual cycle but when a woman is pregnant the placenta takes over responsibility for production. Its main roles consist of preparing the endometrium (internal layer of the uterus) for implanting a fertilised ovum and sustaining pregnancies.  It also plays an important role when a woman is breastfeeding because it helps to prepare the mammary glands for milk production. […]

2018-01-08T11:02:33+02:0012 de January de 2018|0 Comments

Could it be implantation failure why I don’t get pregnant? Diagnosis in one day.

Achieving pregnancy when pregnancy does not come is one of the challenges the medical team at Instituto Bernabeu faces every day. One of the most important challenges of female infertility is implantation failure. The embryo does not get to nest in the maternal uterus or it does but the woman undergoes an early miscarriage, which produces a great frustration. The couple should put themselves as soon as possible in the hands of the specialist and not leave to chance or wait the passage of time to solve a situation that requires a personalized study.
Instituto Bernabeu Medical Director, Dr Rafael Bernabeu explains: “The causes of implantation failure are multiple, but contrary to the general opinion, patients believe they are causing the problem when, in fact, to a great extent the problem is embryonic”. Therefore, the medical centre global benchmark in reproductive medicine develops a study of the three patients: “The mother, the father and the embryo.” Twenty-five percent of embryo implantation failures cases, “do not have a clear cause” and in many cases, there is a combination of factors that can be combined, warns Dr Rafael Bernabeu. Not only are environmental and immunological factors, they are also due to the intake of certain foods and even to the cosmetics used. “We are exposed to tens of thousands of chemical substances and many generate disorders and among them may be the cause of repeated miscarriage and implantation failure,” says Dr Bernabeu. […]

2018-03-26T18:23:03+02:0027 de January de 2017|0 Comments

The endometrial receptivity array (ERA) test

Embryo implantation is the least well known phase of reproduction within the field of reproductive medicine. This fact is of special relevance if we also take into account that the human embryo is not very efficient when compared to other closely-related species in the evolution timeline.
We currently know that pregnancy is based upon three basic pillars: the embryo, the endometrium and the tolerance of the mother’s immune system. Not only is it essential that all three function correctly, but there needs to be optimum interaction between them. We have already covered the role of the embryo and the immune system in detail. Therefore, we will now concentrate on the endometrium and, more specifically, on studying endometrial receptivity. […]

2017-10-02T14:50:28+02:009 de September de 2016|0 Comments

Specialised healthcare in the Instituto Bernabeu endometriosis unit

Endometriosis is the presence outside the uterus of tissue from the uterus known as the endometrium (the lining that covers the uterus where the embryo embeds). It can implant anywhere in the body, except the spleen. […]

2016-08-12T13:45:16+02:008 de March de 2016|0 Comments
Do you need help?