embryo biopsy

What is the impact of vitrification on biopsied blastocysts?

Selecting healthy and viable embryos is increasingly important in the field of assisted reproduction. The selection is made using pre-implantation genetic diagnosis (PGD) which consists of analysing some of the cells in the embryo and determining if it is healthy before it is transferred to the patient.

Embryos can currently be retained in culture until day 5 to […]

2019-06-27T08:51:29+02:0028 de June de 2019|0 Comments

What does an embryo biopsy entail?

Pre-implantation genetic diagnosis (PGD) is a technique that provides a ‘genetic understanding’ of the embryo before it is transferred to the uterus. Thanks to this technique, we are able to study the embryo’s chromosomal make-up and determine if it is a carrier of a hereditary condition of any kind. This information helps us to select the embryos that will lead to the birth of a healthy child. But how do we obtain this information?
Work is currently being carried out to discover non-invasive means of gathering genetic information from the embryo but, to date, the only means is an embryo biopsy. What is an embryo biopsy? […]

2018-01-31T10:04:31+02:002 de February de 2018|0 Comments

New examination aimed at testing couples with recurrent implantation failure

Instituto Bernabeu focusses on providing personalised solutions, particularly in cases of patients with a difficult reproductive prognosis (low ovarian reserve and recurrent implantation failure (RIF)).
Carrying out a number of empirical tests and treatments has, on occasions, been put forward as an option in the case of patients suffering from recurrent implantation failure. The latter have proven to be of questionable efficacy and the former have proven to be of limited or no use.
One of the proposed strategies for patients with recurrent implantation failure (RIF) that is providing many of these cases with solutions, is IVF (in vitro fertilisation) with elective freezing and biopsies on all embryos so that the frozen embryos can later be transferred during a natural cycle. In other words, without any hormone treatment.
It is possible to recreate the conditions under which transfer takes place during treatment of this kind by carrying out a mock cycle and evaluating a series of parameters that can influence transfer success. […]

2017-11-29T10:16:08+02:0030 de June de 2017|0 Comments

The advantages and disadvantages of pre-implantation genetic diagnosis (PGD)

Pre-implantation genetic diagnosis (PGD) consists of studying chromosomal abnormalities and genetic abnormalities in the embryo prior to transfer to the mother. Its purpose is to ensure that children are healthy and put an end to the transmission of a specific condition.
There are two types of PGD: the PGD aimed at selecting embryos that are free of a genetic disorder affecting a single gene (PGD) and the PGD that analyses genetic diseases affecting one or more chromosomes (PGS/PGT-A/CCS or PGS). Their names are sometimes a cause for confusion. The post entitled Are PGD, PGS and CCS all one and the same? clarifies the differences between them. […]

2018-03-28T10:52:16+02:0019 de May de 2017|0 Comments

Recurrent pregnancy loss: an issue that does have a solution

Clearly one of the most difficult situations a couple trying for children may have to face is pregnancy loss. Suffering is even greater when, prior to this, the couple has gone through fertility treatment such as in vitro fertilisation, insemination or egg donation.
Pregnancy loss is not always the result of an illness or underlying abnormality. It can be the response nature provides in order to block the development of an abnormal embryo. In fact, when the tissue from the pregnancy loss is examined, a large number of chromosomal abnormalities can be detected. […]

2016-10-13T12:23:48+02:008 de April de 2016|0 Comments

What does embryo biopsy involve?

Preimplantation Genetic Diagnosis (PGD) is a tool designed to “get to know” the embryos genetically before they are transferred into the mother’s uterus. Thanks to this technique, we can study their chromosome count and find out if they are carriers of a hereditary disease. This information helps us to select the embryos that will produce healthy babies. Yet, how can we find that information?
Today, the only way to find genetic information about embryos is by performing an embryo biopsy. What does embryo biopsy involve?
To explain the biopsy procedure we should keep in mind that our point of departure is EMBRYOS. Embryos are retrieved after performing an assisted reproduction cycle, preferably by Intracytoplasmic Sperm Injection (ICSI), and their development is assessed during the culture period until day 3 or day 5. […]

2016-08-04T13:16:47+02:004 de March de 2016|0 Comments

When will my embryos be biopsied? Why?

During the performance of assisted reproduction procedures, the best embryo is selected for transfer into the mother’s uterus. The selection is based on the “look” of the embryo shortly before transfer. As a matter of fact, waiting time normally stretches until day 5 of embryo culture in order to enhance the potential of the selected embryo and its synchronisation with the endometrium.
Sometimes the selection is favoured by performing a Comprehensive Chromosome Screening (PGS/PGT-A/CCS) test. Thanks to this technique, we can find out if an embryo has all the chromosomes in their exact number, in other words, if it is chromosomally normal. In this way, the selection is both morphological (external look) and chromosomal (internal look).
To be able to analyse the embryo we must first biopsy it (take a cell sample) without affecting its development and subsequent implantation. Biopsy techniques have been evolving until the process has been optimised. […]

2018-03-26T18:06:15+02:0015 de January de 2016|0 Comments
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