A more reliable means of detecting anti-Müllerian hormone and evaluating ovarian reserve

A new, much more reliable, faster technique (results are obtained in 3 days) has been incorporated into our clinic and, since it is carried out directly in our laboratories, it has brought the price down to €50. The technique is carried out on a blood sample which can be taken at our clinics or a sample can be sent to us by courier.
Determining anti-Müllerian hormone levels in a woman’s blood helps us to evaluate ovarian reserve and, along with a transvaginal ultrasound used to carry out an antral follicle count, this provides us with information about her reproductive future and whether or not trying for a child is a matter of urgency.
It can also be used in order to personalise fertility treatment and to help predict how successful it is likely to be.
Cases of couples in clinics in which the female has impaired ovarian reserve are more and more common. A reduction in ovarian reserve of this kind might be expected in older women but not so in younger women, particularly when her menstrual cycles have not been irregular. […]

2016-09-22T17:40:01+02:0023 de September de 2016|0 Comments

The endometrial receptivity array (ERA) test

Embryo implantation is the least well known phase of reproduction within the field of reproductive medicine. This fact is of special relevance if we also take into account that the human embryo is not very efficient when compared to other closely-related species in the evolution timeline.
We currently know that pregnancy is based upon three basic pillars: the embryo, the endometrium and the tolerance of the mother’s immune system. Not only is it essential that all three function correctly, but there needs to be optimum interaction between them. We have already covered the role of the embryo and the immune system in detail. Therefore, we will now concentrate on the endometrium and, more specifically, on studying endometrial receptivity. […]

2017-10-02T14:50:28+02:009 de September de 2016|0 Comments

What is the significance of FSH hormone levels in fertility?

Follicle-stimulating hormone (FSH) is essential to reproduction. It is produced by the pituitary gland situated just below the brain (behind the palate) and is released into the bloodstream. The hormone regulates the ovaries and is involved in the processes dealing with the growth and selection of the follicle which will later release the egg during ovulation.
Fluctuations in FSH levels are responsible for menstrual cycles and also for the fact that only one egg is produced during each cycle. It is essential, therefore, that there is constant dialogue between the ovaries and the pituitary gland so that the latter can consistently produce the correct quantity of FSH for a normal cycle.
This permanent exchange means that, in cases of poor ovarian function, the pituitary gland will try to compensate for this situation by increasing FSH excretion levels. It is for this reason that FSH levels in women going through the menopause are 20 times greater than in women whose ovaries are functioning normally. Therefore, when the ovary does not respond correctly, FSH increases significantly and systematically. […]

2016-08-12T14:21:26+02:0022 de July de 2016|0 Comments

The 600 recessive disorders detected by the Genetic Compatibility Test (GCT)

Nowadays, all couples who wish to avoid passing on genetic disorders to their children can choose to do so through a Genetic Compatibility Test (GCT), also known as Prenatal Recessive Disorder Screening.
The Instituto Bernabeu GCT is a groundbreaking analysis that uses next-generation DNA sequencing (NGS) through which we study 555 genetic mutations which cause over 600 autosomal recessive disorders in a simple blood sample.

Please see below the list of mutations analysed by the GCT we do at INSTITUTO BERNABEU:

The 613 recessive diseases detected by the Genetic Compatibility Test (GCT), from 1st of July 2020

The 600 recessive disorders detected by the Genetic Compatibility Test (GCT)
13 new recessive diseases detected by the Genetic Compatibility Test (GCT), from 1st of  July 2020

GENE
LOCUS
DISEASE
OMIM

SERPINA1
14q32.13
Alpha-1-antitrypsin deficiency
613490

SPG7
16q24.3
Autosomal recessive spastic paraplegia type 7
607259

OCA2
15q12
Oculocutaneous albinism type 2
203200

SLC26A4
7q22.3
Autosomal recessive non-syndromic sensorineural deafness type DFNB/Pendred syndrome
274600

CLCN1
7q34
Thomsen and Becker disease
160800

TYR
11q14.3
Oculocutaneous albinism type 1A
203100

CAPN3
15q15.1
Calpain-3-related limb-girdle muscular dystrophy R1
253600

CRB1
17p13.1
Leber congenital amaurosis
204000

GALNS
16q24.3
Mucopolysaccharidosis type 4A
253000

OTOF
2p23.3
Autosomal recessive non-syndromic sensorineural deafness type DFNB
601071

SAG
2q37.1
Retinitis pigmentosa 47
613758

TMPRSS3
21q22.3
Deafness, autosomal recessive 8/10
601072

TSHR
14q31.1
Hyperthyroidism
603373

The 600 recessive disorders detected by the Genetic Compatibility Test (GCT)
[…]

2021-01-14T10:44:40+02:0025 de May de 2016|0 Comments

Recurrent pregnancy loss: an issue that does have a solution

Clearly one of the most difficult situations a couple trying for children may have to face is pregnancy loss. Suffering is even greater when, prior to this, the couple has gone through fertility treatment such as in vitro fertilisation, insemination or egg donation.
Pregnancy loss is not always the result of an illness or underlying abnormality. It can be the response nature provides in order to block the development of an abnormal embryo. In fact, when the tissue from the pregnancy loss is examined, a large number of chromosomal abnormalities can be detected. […]

2016-10-13T12:23:48+02:008 de April de 2016|0 Comments

Specialised healthcare in the Instituto Bernabeu endometriosis unit

Endometriosis is the presence outside the uterus of tissue from the uterus known as the endometrium (the lining that covers the uterus where the embryo embeds). It can implant anywhere in the body, except the spleen. […]

2016-08-12T13:45:16+02:008 de March de 2016|0 Comments

Instituto Bernabeu begins research on a new treatment for patients with poor ovarian response

From January 2016, Instituto Bernabeu will work on a clinical trial (free to participating patients) with the aim of evaluating the efficiency of a line of treatment in patients with poor response to ovarian stimulation.
The research, which has already been approved by the Spanish Drug Agency and has been published in the USA National Health Institute register, involves comparing ovarian response to two different stimulation protocols. One is conventional with drug administration starting at the beginning of the cycle. The other, new procedure carries out stimulation once it has been confirmed that the patient is ovulating. […]

2016-08-12T13:40:17+02:0027 de January de 2016|0 Comments

Stregth position in the congress of the British fertility society

The British Fertility Society (BSF) Annual Congress, one of Europe’s leading fertility and assisted reproduction events, was held on 7th and 8th January in Newcastle (UK). Its scientific committee accepted a total of 11 pieces of research work prepared by Instituto Bernabeu (Alicante) as part of the group’s main lines of R&D. These include poor ovarian response – a […]

2020-11-27T10:06:26+02:0014 de January de 2016|0 Comments

Fertility research: one of a kind treatment for one of a kind patients

Research in the field of assisted reproduction provides us with more and more answers to situations which previously had none. It gives us solutions, options and new ways of overcoming the many difficulties which arise in reproduction.  What’s more, progress in science also helps diagnosis and treatment to be increasingly specific, personalised and individual. In fact, we might even say that the aim is to reach a point where one of a kind treatments are designed for one of a kind patients. […]

2018-03-26T18:11:08+02:0017 de July de 2015|0 Comments

Low ovarian reserve, a challenge with optimistic future

The social changes in recent years have been highly beneficial to achieving rights and equalities, although it has also led to a significant increase in maternal age. But nature does not understand social change and the biological clock keeps ticking as usual. There are several consequences of this delay on female fertility and it depends on each woman, but it is a reality that as women age, the ovarian reserve diminishes and the egg quality lowers. […]

2021-01-20T10:57:11+02:0017 de June de 2015|0 Comments
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