Instituto Bernabeu exposes in the scientific journal Fertility and Sterility the ovary epigenetics in women with low eggs reserve

  • 31-03-2021

The team formed by doctors Belen Lledo, Jose Antonio Ortiz and Rafael Bernabeu have carried out an analysis on the epigenetic profile of women with low ovarian reserve which has just been published in the scientific journal of the American Society for Reproductive Medicine (ASRM) , Fertility and Sterility.

Epigenetics studies the changes that occur in the genes function, their activation or deactivation, without involving DNA modification. Epigenetic marks change the way genes are expressed.

The work opens a new line of action that passes through the possibility of reprogramming the ovary with the use of drugs to reverse the modification patterns that lead to inadequate folliculogenesis.

The Instituto Bernabeu team analyzes the work “Identification of a unique epigenetic profile in women with diminished ovarian reserve” led by Dr. Kristina W. Olsen. Among other aspects, the research concludes that women with decreased ovarian reserve have a different epigenetic profile in the cells of their ovarian follicles. This fact makes them different from patients with a normal or high ovarian reserve.

The Instituto Bernabeu team analyzes the work “Identification of a unique epigenetic profile in women with diminished ovarian reserve” led by Dr Kristina W. Olsen. Among other aspects, the research concludes that women with decreased ovarian reserve have a different epigenetic profile in the cells of their ovarian follicles. This fact makes them different from patients with a normal or high ovarian reserve.

In an assisted reproductive treatment, the prognosis greatly depends on the number of eggs obtained after ovarian stimulation. When it’s low, the chance of pregnancy is reduced. Although age often marks the decreasing number of eggs, not all women with a similar age have the same ovarian reserve. There’re many studies to help us understand and be able to address low ovarian reserve. And the one that has just been published is very innovative and emphasizes the study of the epigenetics of the ovary.

 

Exploring the epigenetic profile of women with poor ovarian reserve

R. Bernabeu, JA Ortiz, B. Lledo

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