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The endometrial receptivity array (ERA) test

Embryo implantation is the least well known phase of reproduction within the field of reproductive medicine. This fact is of special relevance if we also take into account that the human embryo is not very efficient when compared to other closely-related species in the evolution timeline.
We currently know that pregnancy is based upon three basic pillars: the embryo, the endometrium and the tolerance of the mother’s immune system. Not only is it essential that all three function correctly, but there needs to be optimum interaction between them. We have already covered the role of the embryo and the immune system in detail. Therefore, we will now concentrate on the endometrium and, more specifically, on studying endometrial receptivity. […]

Diagnostic hysteroscopy and endometrial scratching

We consider an evaluation of the uterine cavity and a check to ensure normal structure in the tissue that lines it (the endometrium) to be a standard part of any implantation failure study. In order to carry out such a study, the most appropriate diagnosis consists of a diagnostic hysteroscopy and an endometrial biopsy.
A hysteroscopy is an endoscopy of the uterus. In other words, direct inspection of the uterine cavity using an optical system. It’s a simple test and practically pain free in most cases. Therefore, it is generally carried out during an appointment with minimal patient preparation and no impact on her daily life. […]

Recurrent pregnancy loss: an issue that does have a solution

Clearly one of the most difficult situations a couple trying for children may have to face is pregnancy loss. Suffering is even greater when, prior to this, the couple has gone through fertility treatment such as in vitro fertilisation, insemination or egg donation.
Pregnancy loss is not always the result of an illness or underlying abnormality. It can be the response nature provides in order to block the development of an abnormal embryo. In fact, when the tissue from the pregnancy loss is examined, a large number of chromosomal abnormalities can be detected. […]

State of the art technology in preimplantation embryo diagnosis: Array-CGH

Preimplantation Genetic Diagnosis (PGD) is the study of chromosomal and genetic abnormalities in embryos before they are transferred to the mother’s uterus by an In Vitro Fertilisation (IVF) technique. It seeks to ensure healthy offspring and stop transmission of a given disease. […]

Instituto Bernabeu strengthens is position as a European reference in matters of R&D at the Annual Congress of the British Fertility Society.

The British Fertility Society (BSF) Annual Congress, one of Europe’s leading fertility and assisted reproduction events, was held on 7th and 8th January in Newcastle (UK). Its scientific committee accepted a total of 11 pieces of research work prepared by Instituto Bernabeu (Alicante) as part of the group’s main lines of R&D. These include poor ovarian response – a pathology which is largely associated with attempts to fall pregnant later on in life –  embryo implantation failure and the impact of genetics on reproduction issues. […]

Adenomyosis and recurrent implantation failure

Adenomyosis occurs when the tissue that lines the inner part of the uterus (the endometrium) is found in the outermost part of the uterus (myometrium), which is a muscle layer. It is sometimes referred to as endometriosis of the uterus, given that endometrial tissue is found where it should not be, just like it happens in endometriosis.
Until recently, the knowledge we had about endometriosis was close to non-existent, except for those patients who had had their uterus removed and close examination had yielded this finding. Even so, its connection with heavy bleeding and pain during menstruation was well known, and also with uterus enlargement as a result of such abnormal bleeding.
Our knowledge of this pathology has blossomed over the last five years, when, thanks to the advances achieved in ultrasound scanning, gynaecologists have been able to diagnose it. Until then, this condition could only be suspected when performing a magnetic resonance or examining the uterus directly. It is very interesting to see on 3D ultrasound scans the endometrial cavity and the myometrium look as if they had merged into one and see the inner part of the endometrium reach out to the outer part. […]

Fertility research: one of a kind treatment for one of a kind patients

Research in the field of assisted reproduction provides us with more and more answers to situations which previously had none. It gives us solutions, options and new ways of overcoming the many difficulties which arise in reproduction.  What’s more, progress in science also helps diagnosis and treatment to be increasingly specific, personalised and individual. In fact, we might even say that the aim is to reach a point where one of a kind treatments are designed for one of a kind patients. […]

Embryo implantation, the ultimate test

It’s the miracle of life: fertilization and human reproduction. A meticulous and perfect process that allows two cells to come together and create another that will develop until transforming into a new being. […]

Genetic approach to embryo implantation failure and repeated miscarriage

Couples that don’t achieve pregnancy after in vitro fertilization treatments and those who lose their pregnancy in early stages require a multidisciplinary approach in order to diagnose and treat their reproductive problem.
 
From a genetic point of view, these patients are more likely to produce embryos with chromosomal abnormalities. To improve these couples’ pregnancy rates, the preimplantational genetic diagnosis (PGD) can be applied. In these cases, the goal is to select the embryos with the highest capacity of resulting in an ongoing pregnancy thanks to the fact that the PGD allows us to identify the number of chromosomes in the embryo. Only embryos with the correct number of chromosomes can lead to a healthy child, others will arrest in their development or will lead to a miscarriage. […]

Endoscopic surgery in fertility treatments

Endoscopic surgery is by definition performed by accessing the site of intervention, either an organ or cavity, through natural or artificial orifices by using an optical system with camera and light that allows us to see what is going to be performed on a television monitor. Surgical manipulation is also done in these orifices or “ports” of entry. […]

By |29 de July de 2013|Gynaecology, News, Uncategorized, Women’s health|0 Comments