New diagnosis technique for male sterility and missing genetic material (Y chromosome microdeletions).

We all have 46 chromosomes: 23 of them are inherited from our father and 23 are from our mother. The genetic information for our entire body is stored within these chromosomes. Two of the 46 are sex chromosomes and determine whether we are male (XY) or female (XX). Therefore, the Y chromosome contains all the necessary information for differentiating males from females as well as for sperm production.
The study of Y chromosome microdeletions consists of checking if chromosome Y is complete and, as such, has all the necessary information for satisfactory sperm production or if, on the contrary, small fragments are missing. The loss of such fragments leads to altered spermiogramme which can mean poor sperm production (oligozoospermia) or even no production at all (azoospermia). […]

By |23 de September de 2015|Fertility, Genetics, Reproductive biology, Sterility, Urology|0 Comments

Semen quality parameters according to the World Health Organisation (WHO)

The spermiogram is a basic tool that provides us with some of the best information to assess male fertility. It is also very useful in order to formulate a personalized treatment plan for the couple.
The World Health Organisation (WHO) has published several editions of the “Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction”, the last one in 2010. Those manuals help and guide andrology laboratories to determine sperm quality. Moreover, in recent years, the European Society for Human Reproduction and Embriology (ESHRE) in collaboration with the WHO have developed a program to improve standardization between laboratories in terms of sperm sample diagnosis and assessment criteria. […]

Contamination, environmental toxins and fertility

Scientific evidence from the last 15 years shows that without a doubt, environmental toxins before conception and during pregnancy cause long-lasting effects on reproductive health. An example of this is the exposure to mercury, which causes cognitive impairment in children. Another example is the exposure to agricultural pesticides, which is associated with sperm quality alterations and higher incidence of testicular and prostate cancer for men, and in women it interferes with the development of puberty, ovulation, fertility and menopause. […]

Using Magnetic Fields to Select Healthy Sperm: MACS (Magnetic Activated Cell Sorting)

It is well known that having the best possible sperm quality is important to the success of assisted reproduction techniques. To achieve this, the lab has to improve sperm quality based on its motility and morphology, selecting the sperm that is considered to be the best.
However in every ejaculate sperm with abnormal membranes are found, which are programmed to “die”. This process is called apoptosis, or programmed cell death.   Approximately 20% of sperm in subfertile patients are  thought to be in the process of “celular death”. […]

Instituto Bernabeu´s specialised unit for the treatment of Klinefelter´s Syndrome and fertility.

Klinefelter’s Syndrome is considered the most common chromosomal abnormality  in humans, with an incidence of 1 out of every 500 newborn males. Those affected by this syndrome have an extra X chromosome, which leads to primary testicular failure and therefore infertility and hypoandrogenism.


By |24 de September de 2012|Fertility, News, Sterility, Urology|0 Comments

IB implantation failure and repeated miscarriage unit

At Instituto Bernabeu, we have developed a specific programme with protocols designed to treat repeated miscarriages and unsuccessful assisted reproduction treatments through the multidisciplinary approach that allows us to diagnose and therefore overcome these problems.


Azoospermia in the IVF lab

Azoospermia is defined as the absence of sperm in the ejaculate, which is generally classified as either obstructive or secretory. In obstructive azoospermia, the sperm cells cannot complete their journey from the testicle to the urethra through the seminal tract; however, the sperm cells are produced in the testicle (spermatogenesis). […]

By |11 de January de 2012|Fertility, Sterility, Uncategorized, Urology|1 Comment

Spermiogramme and Advanced Semen Studies (FISH AND TUNEL)

A seminogramme or spermiogramme is one of the basic studies performed on men to determine the sperm quality. Sperm is analysed from both a macroscopic and microscopic viewpoint. The most relevant parameters of the study are threefold:
–          Sperm count
–          Sperm motility
–          Sperm morphology