Archive for the 'Assisted reproduction' category

How many eggs on average are donated on an Egg Donation treatment at Instituto Bernabeu?

01 In Spain, we performed 40% of all egg donation cycles in Europe. The experience accumulated at Instituto Bernabeu for over 15 years, allows us to offer to our patients a high quality and personalized treatment.

When a patient decides to go for an Egg Donation treatment, a chain work is set in the organization, in which we guarantee a commitment of trust, reliability and professional quality.

Why an “x” number of eggs are donated? Why not only one?

We need to keep in mind that in the developing process of a fertility treatment, there are a number of facts subject to human biology itself.

To begin with, not all the eggs collected will be suitable to be fertilized. Only those ones that have achieved an adequate maturity will have that option. Not all the mature eggs will get fertilize and some others will have an abnormal fertilization so there will be discarded for a possible transfer.

The eggs fertilized with normalcy that is the generated embryos from the fertilization, will have a different pattern. Each embryo has its own destination. Some will get blocked during the observation period before the transfer, some others will survive until the transfer day but with bad or low quality, and only a few will have an adequate morphology and development to be selected for the embryo transfer. This is a completely normal development that happen in all assisted reproduction cycles both with own eggs and donated eggs.

Sometimes, patients understand the “loss” of embryos as a poor outcome. How these can happen if we had so many embryos and we ended up with just a few? The main reason is natural biological selection within the absolute normality.

At Instituto Bernabeu the egg donor is selected individually in each case, ensuring the maximum similarity with the recipient patient, and is treated in a safe and controlled manner to guarantee obtaining an adequate number of eggs, always under close medical supervision.

The average age of an egg donor in our clinic is 25 years old. After the ovarian stimulation we retrieve all the eggs possible. Currently our average number of donated eggs is 12 per cycle. The rate of mature eggs is 90%, this demonstrate the proper selection of egg donors and the correct enforcement of the ovarian stimulation patterns.

The fertilization rate, that is the number of embryos generated by the amount of eggs fertilized, is 75%. From this point onwards and as I explained above, each embryo will have a different development.02But not only is the number of eggs retrieved important, the quality is essential. This is determined primarily by the age of the woman, a comprehensive selection of the egg donor, the quality in the implementation of stimulation protocols and the fact that many egg donors have previous proven fertility. This allows performing the embryo transfer, in a high percentage of cases, the 5th day of embryonic life (for the most advanced embryonic development called blastocyst).

The entire set of facts can offer our patients the possibility of transferring a high number of quality embryos, in fact 60% of cycles quality embryos can be frozen (vitrified) with a cumulative pregnancy rate of 85% per cycle.

This is especially important in the group recipient patients to who, in many cases, by age or medical history or by choice is decided to transfer a single embryo to avoid the risk of twin pregnancy.

The quantity and quality of eggs donated per cycle at our center ensures the highest probability of normal to term pregnancy.

Dr. Lydia Luque, Gynecologist at Instituto Bernabeu.

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You can arrange an online consultation or book an appointment at Instituto Bernabeu.

More information on our website: www.institutobernabeu.com/en/ or www.ibbiotech.com

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Semen quality parameters according to the World Health Organisation (WHO)

01The spermiogram is a basic tool that provides us with some of the best information to assess male fertility. It is also very useful in order to formulate a personalized treatment plan for the couple.

The World Health Organisation (WHO) has published several editions of the “Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction”, the last one in 2010. Those manuals help and guide andrology laboratories to determine sperm quality. Moreover, in recent years, the European Society for Human Reproduction and Embriology (ESHRE) in collaboration with the WHO have developed a program to improve standardization between laboratories in terms of sperm sample diagnosis and assessment criteria. Continue Reading »

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Embryonic arrest, why don’t all of my embryos develop equally?

01.Embrion-Humano-10-celulas_-Dia-3When one starts an in vitro fertilisation (IVF) treatment, one of the most frequent concerns is the number of high quality embryos that can be obtained.

This number is variable and depends on several factors such as the ovarian reserve and gamete quality (egg and sperm). Once the eggs are fertilised, they are considered embryos, which begins after their early division. The embryo division is observed in the IVF laboratory on a daily basis and is key information to determine the embryo quality. The Spanish Association of Reproductive Biology (ASEBIR) establishes a classification according to various observed morphological parameters, which indicate the embryo quality according to their capacity to implant in the womb. Continue Reading »

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Contamination, environmental toxins and fertility

Instituto BernabeuScientific evidence from the last 15 years shows that without a doubt, environmental toxins before conception and during pregnancy cause long-lasting effects on reproductive health. An example of this is the exposure to mercury, which causes cognitive impairment in children. Another example is the exposure to agricultural pesticides, which is associated with sperm quality alterations and higher incidence of testicular and prostate cancer for men, and in women it interferes with the development of puberty, ovulation, fertility and menopause. Continue Reading »

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Is it beneficial to rest after the embryo transfer?

reposoWithout a doubt, one of the most emotionally stressful stages a patient undergoing IVF has to face is the period between the embryo transfer and the pregnancy test result.

It is a natural instinct for someone in this situation to want to do everything in her power to increase the chances of success, which is why she is extra sensitive to any messages she receives from family members, friends, the internet, etc. This leads to a confusing situation because oftentimes the advice received is contradictory. As if that weren’t enough, the vast majority is unfounded and not validated by any scientific evidence. Their question is often “should I rest or not?Continue Reading »

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Avoiding multiple pregnancy: Why is it important to avoid pregnancy of twins or triplets?

trillizosMultiple pregnancy is, along with ovarian hyperstimulation, the most significant complication in fertility treatments.

Most couples that go through assisted reproduction techniques consider multiple pregnancies to be desirable or the lesser evil. However, pregnancies of twins and even more so triplets are associated with a series of complications that challenge the pregnancy ending in the birth of a healthy baby. Let us not forget that the birth of a healthy baby is the only objective of assisted reproductive techniques. Continue Reading »

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ROPA method: Shared Maternity

Metodo ROPA

ROPA (Reception of Oocytes from PArtner, or Partner Assisted Reproduction) is a treatment in reproductive medicine that allows married same sex female couples to both participate in the important act of creating a family.

This treatment allows one of the women in the couple to give her eggs (the genetic material that is passed on to the baby), and the other woman will carry the pregnancy. Continue Reading »

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Unraveling the mysteries of ICSI (Intracytoplasmic sperm injection)

IFRAME Embed for Youtube

We’re dedicating this Instituto Bernabeu forum topic to a very common technique used in the human reproduction laboratory: ICSI or Intracytoplasmic sperm injection. We have prepared this explicative video on the topic, in which Dr. Jorge Ten simply explains what this technique involves, how it is performed, its indications, history and evolution, as well as our reproductive biology team’s efforts to perfect the results. We hope you like it! Continue Reading »

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Endometriosis and Fertility

Endometriosis is a benign condition in women involving the appearance and growth of endometrial tissue, typical of the uterus, outside this organ. It most frequently appears in the ovaries and rarely outside the abdomen (in the lungs, etc.).

Every time a woman menstruates, this tissue also bleeds but is not able to leave the body. This is when pain, inflammation and fibrosis appear and in some cases, fertility problems.

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Discretionary use of intralipids in patients undergoing Assisted Reproduction Techniques

There has been a lot of discussion about therapies aimed at improving pregnancy rates; especially in patients that have gone through several cycles of treatment without positive results.

This is one of the most frustrating situations that doctors and patients can possibly have.

The inevitable question is: What can we do to improve our chances? Isn’t there anything new?

We think that patients who have received 4 or more high quality embryos without any pregnancy should be thoroughly evaluated through an implantation failure study that should include the three fundamental elements for success: the female, male and embryo factors.

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