Scientific Publications

Publications of the IB in international newspapers




  

 

  • Uterine arteriovenous malformation. British Medical Journal (BMJ) Case Rep 2013.doi: 10.1136/bcr-2012-008443. February 2013.F. Sellers, A. Palacios, B. Moliner, R. Bernabeu.

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Deletion of chromosome 13: 46, XY del (13) (q14->qter) after in vitro fertilization and tubal embryo transfer. Journal of Assisted Reproduction and Genetics, Vol. 13, No 6. July 1996. M. Bonada, N. Cremades, F. Galán, R. Bernabeu.

 

 

Conference

BFS Annual Meeting 2014. Sheffield, UK. January 2014 

 

 7th ASEBIR Conference. Seville. Spain. November 2013. 

 
 

ASRM Annual Meeting. Boston, Massachusetts, USA. October 2013  

  • Ovarian vascularization analyzed by 3D power doppler angiography ultrasound predicts the number of mature oocytes in poor responder patients. B. Moliner, J. Llácer, F. Sellers, L. Luque, J. Guerrero and R. Bernabeu. 
  • Is the obstetric outcome of poor ovarian responders different from normal responders? An age-matched controlled study. J. Llácer, P. Baviera, I. Calventus, J. Guerrero, J. Ten and R. Bernabeu. 
  • Prediction of low ovarian reserve using a multifactorial genetic model. J. Ortiz, J. Llácer, A. Turienzo, R. Morales, B. Lledó and R. Bernabeu. 
  • Polymorphisms in inmune pathway genes (IL11 and PRRC2A) are associated withpoor ovarian response. J. Llácer, J. A. Ortiz, A. Turienzo, L. Luque, B. Lledó and R. Bernabeu. 
  • Should embryos coming from donated eggs be evaluated with the same criteria as those from own oocytes? Emerging evidence for a new score. J. Llácer, J. Ten, D. Rodriguez, I. Ochando, J. Guerrero and  R. Bernabeu. 
  • Oxidative stress assessed in the ejaculate is not related with sperm DNA damage. J. Llácer, J. Ten, R. Bernabeu, A. García-Peiró, M.C. Díaz and J. Gosálbez.

 

 

ESHRE Annual Meeting. London. July 2013

  • Effect of chromosome polymorphic variants in the infertility and their relationship with the IVF cycles outcome. Morales, R., Lledó, B., Ortiz JA,  Ten J., Llácer, J., Bernabeu, R.
  • Effect of follicle-stimulating hormone receptor N680S polymorphism in the efficacy of follicle stimulating hormone stimulation on donor ovarian response. Turienzo, A., Lledo, B., Guerrero, J., Ortiz, JA., Morales R., Ten, J., Llacer, J., Bernabeu, R.
  • Relevance of R72P p53 single nucleotide polymorphism in the outcome of IVF cycle in patients with repeated implantation failure and pregnancy loss. Lledo, B., Turienzo, A., Ortiz, JA., Morales R., Ten, J., Llacer, J., Bernabeu, R.
  • Final outcome of embryo transfers on day 3, 4 and 5 using own and donated oocytes. Rodríguez, A., Ten, J., Guerrero, J., Ochando, I, Pérez, M.D., Bernabeu, R.
  • Should testosterone be used for more patients than only low ovarian responders?. Pérez, M.D., Ten, J., Guerrero J., Araico, F., Llácer J.; Bernabeu, R.
  • Dropout evaluation during egg donor screening. Guerrero, J., Ten, J., Giménez, J., Llácer, J., Bernabeu, R.

 

The European Human Genetics Conference 2013. Paris, France, June 8-11, 2013

  • N680S polymorphism on the FSHR gene and its effect on ovarian donor follicle stimulating hormone stimulation. J.A. Ortiz, A. Turienzo, B. Lledo, J. Guerrero, R. Morales, J. Ten, J. Llacer, R. Bernabeu.
  • R72P p53 single nucleotide polymorphism in patients with repeated implantation failure and pregnancy loss: influence in the outcome of IVF cycle. B. Lledo, A. Turienzo, J.A. Ortiz, R. Morales, J. Ten, J. Llacer, R. Bernabeu.
  • Chromosome polymorphic variants in infertility and their effect on ongoing pregnancy rates. R. Morales, B. Lledó, J.A. Ortiz, J. Ten, J. Llácer, R. Bernabeu.

 

XXVII Spanish Human Genetics Association National congress. Madrid. April 2013

  • Effect of polymorphism (TA)n in the promoter estrogen receptor alpha (ER) on sperm and follicle count. Ortiz J.A., Lledó, B., Morales, R., Turienzo, A., Llácer, J., Bernabeu, R.
  • Effect of SNP N680s in FSH receptor over ovarian stimulation. Morales, R., Lledó, B., Guerrero, J., Turienzo, A., Ortiz, J. A., Ten, J., Llácer, J., Bernabeu, R.
  • Effect of the expansion in the normal and intermediate range in the FMR1 gene (FRAGILE X) over ovarian response. Lledó, B., Guerrero, J, Ortiz, J.A., Morales, R., Ten, J., Llácer, J., Bernabeu, R
  • Polymorphism analysis of the androgen receptor (AR) and the FSH hormone (FSHR) and its relationship with premature ovarian failure. Turienzo, A., Lledó, B., Ortiz, J.A., Morales, R., Luque, L., Araico, F., Rodríguez, Llácer, J., Bernabeu, R

 

Fertility 2013. BFS. Liverpool. January 2013.

  • Intermediate and normal sized CGG repeat on the FMR1 (fragile X) gene does not affect ovarian response in oocyte donor. B. Lledó, J. Llácer, R. Bernabeu.
  • Does donor age affect the final outcome in egg donation treatments?. J. Guerrero, J. Llácer, R. Bernabeu.
  • Day 4 versus day 5 embryo transfer in an egg donation program. J. Guerrero, J. Ten, J. Llácer, R. Bernabeu.
  • Main causes of rejection during egg donor selection process. J. Guerrero, J. Ten, J. Llácer, J. Giménez, R. Bernabeu.

 

68th ASRM Annual Meeting. San Diego, California. October 2012

  • Androgen receptor Polymorphisms are associated with poor ovarian response. J. Llácer, J.A. Ortiz, J. Guerrero, B. Lledó, J. Ten, R. Bernabeu. 
  • Sperm deoxyribonucleic acid fragmentation level, as measured by tunel test, is not related with the IVF outcome in good prognosis women. B. Lledó, R. Morales, A. Rodríguez, J. Ten, R. Bernabeu.   
  • High ovarian stimulation doesn't impair embryo quality. Clinical evidence using comparative model with shared egg donors. J. Llácer, B. Moliner, A. Rodríguez, J. Guerrero, J. Ten, R. Bernabeu. 
  • Effect of polymorphism in the promoter estrogen receptor alpha on sperm count. B. Lledó, A. M. Fabregat, R. Morales, J. A. Ortiz, J. Llácer, R. Bernabeu.

 

XII National Conference of the Spanish Association for Menopause Studies (AEEM). Alicante, June 2012

  • Genetic study of the X-Fragile Syndrome on patients with premature ovarian insufficiency. Lozano Pérez, J.M, Lledó Boch, B. Ortiz Salcedo, J.A., Llácer Aparicio, J., Bernabeu Pérez, R.

 

29th National Conference of the Spanish Fertility Society (SEF). Granada, May 2012

  • Effect of expansion in the FMR1 gene (Fragile X) on ovarian response.
  • Effect of sperm DNA fragmentation in our egg donation programme using conventional IVF.
  • Effect of IVF on the chromosomal anomalies in miscarriage prognosis of patients with repeated miscarriages.
  • Relationship between polymorphism (CAG)n on exon 1 of the androgen receptor (AR) and low ovarian reserve.
  • Effect of the polymorphism (TA)n alpha Oestrogen Receptor promoter (ERalfa) on follicle and sperm count.
  • Comparative study between ET on D+3 and D+5.
  • Results of the egg donation programme with transferred eggs.
  • Optimization of the time of ET after embryo thawing.
  • Embryo transfer on day 2 versus day 3 in low responders.
  • Clinical results in patients with low response.
  • Effect of the embryo culture under low concentrations of oxygen.
  • Reduced embryo quality in patients with OTA and the influence on pregnancy rates.
  • The binding capacity of sperm to the zona pellucida and the induction of the acrosome reaction are not affected after oocyte vitrification.
  • Effect of the fertilisation technique in low responders.

 

27th National Obstetric and Gynaecological Ultrasound Conference of the SEGO (Spanish Society of Gynaecology and Obstetrics) -SESEGO-. Madrid, May, 2012.

  • AWARDED WITH THE "LUIS TADEO MERCÉ ALBERTO" PRIZE FOR THE BEST PRESENTATION OF "GYNAECOLOGY ULTRASOUND" with the speech:"Analysis and volume of uterine and ovarian vascularisation with their corresponding relationship in the oocyte response of In Vitro Fertilisation cycles." B.Moliner, F. Sellers, A. Palacios, L.Luque,J.Llacer, R.Bernabeu
  • Uterine arteriovenous malformation. New contributions to its pathogenesis
  • Angio-Power 3D Doppler. New tool to predict low ovarian response.

 

VI Conference ASEBIR. Gerona. October 2011.

  • Comparison of results from day 4 vs day 5 transfers in an egg donation programme. J. Guerrero; J. Ten; M. Pérez; J. Llácer; R. Bernabeu
  • Distribution patterns of cannabinoid receptors CB1 and CB2 in fresh human achrosome reacted and prepared sperm. M.M. Francou; E. García-Hernández; J.L. Girela; M.J. Gómez-Torres; J. Ten; R. Bernabeu; J. De Juan
  • Effect of endocannabinoids 2- Arachidonylglycerol (2-AG) and 2- Arachidonyglycerol ether (2-AGE) on in vitro functions of human sperm cells. M.M. Francou; E. García-Hernandez; J.L. Girela; M.J. Gómez-Torres; J. Ten; R. Bernabeu; J. De Juan
  • Effectiveness of embryo vitrification on day 4. J. Guerrero; J. Ten; M. Pérez; J. Llácer; R. Bernabeu
  • ELONVA: First cycles at Instituto Bernabeu. M. A. Carracedo; J. Ten; J. Guerrero; R. Bernabeu; J. Llácer
  • What is the best embryo development stage for transferring and freezing? Overall assessment of IVF cycles. M. A. Carracedo; J. Ten; J. Guerrero; J. Llácer; R. Bernabeu
  • Evaluation of embryo kinetics and morphology in patients with repeated implantation failure. J. Ten; J. Guerrero; J. Llácer; R. Bernabeu
  • Effect of polymorphism (TA)N of ALPHA (ERA) estrogen receptor promoter on sperm count. A. Ortiz; B. Lledó; R. Morales; J. Llácer y R. Bernabeu.
  • Effect of expansion in the FMR1 (FRAGILE X) gene on ovarian response. Lledó B.; Guerrero J.; Ortiz JA; Morales R.; Ten J.; Giménez J.; Llácer J.; Bernabeu R.
  • Single cell comparative genomic hybridisation (SC CGH): a new tool for preimplantation genetic screening (PGS).Lledó B.; Ortiz JA; Morales R.; Bernabeu R.

 

67th ASRM Annual Meeting.Orlando.Florida.October 2011

  • Clinical outcomes in an egg donation program derived from day 4 versus day 5 embryo transfer.

 

27th Annual Meeting of the European Society of Human Reproduction & Embryology. ESHRE. Stockholm , Sweden, July 2011

  • Day 3 or day 5 embryo transfer?: a randomized prospective study. J. Ten, M.A. Carracedo, J. Guerrero, A. Rodríguez-Arnedo, J. Llácer, R. Bernabeu.

 

European Human Genetics Conference. Gothenburg, Sweden. June 2010.

  • The paternal effect of chromosome translocation carrier in the embryos meioic segregation. B. Lledó, J. A. Ortiz, R. Morales, A. Rodríguez-Arnedo, J. Ten, J. Llácer and R. Bernabeu
  • A new accuracy method to undocumented embryo diagnosis. A. Rodríguez-Arnedo, J. Ten, J. Guerrero-Villena, B. Lledó, J.A. Ortiz, :. Carracedo, J. Llácer and R. Bernabeu.

 

26th Annual Meeting of the European Society of Human Reproduction & Embryology. ESHRE , Rome, Italy, June 2010.

  • How we could rescue undocumented embryos with a common paternity test? Rodríguez-Arnedo, A., Ten, J., Guerrero, J., Lledó, B., Carracedo, M.A., Ortiz J. A., Llácer, J., Bernabeu.

 

28th Annual National Conference of the Spanish Fertility Society. Valencia. May 2010

  • Metabolomics as a non-invasive method to select embryos. National research award for the best basic communication.
  • The use of GnRH agonists do not improve the results in Cryotransfer cycles with cryopreserved embryos. J. Guerrero, J. Ten, A. Rodríguez-Arnedo, M.A. Carracedo, J. Llácer, R. Bernabeu.
  • The paternal or maternal effect of chromosome translocation carriers observed from meiotic segregation in embryos. Lledó B., Ortiz JA, Morales R, Rodríguez-Arnedo A., De la Fuente P, García-Ochoa C, Bernabeu R.
  • Antioxidant treatment effect in patients with sperm DNA fragmentation and the outcome of IVF cycles . Morales R, Lledó B, Ortiz JA, Ten J, Guerrero J., Luque L, Bernabeu R.
  • Chromosomal Polymorphisms and Infertility. Morales R, Lledó B, Ortiz JA, Quintana J, Llácer J, Bernabeu R.
  • From 2001 to 2009: Older women, better IVF results. Jorge Ten Morro, Jaime Guerrero Villena, Joaquín Llácer Aparicio, José Manuel Lozano Pérez, Elena. García-Llopis, Rafael Bernabeu Pérez.
  • A new and more reliable method to diagnose non-documented embryos. Rodríguez-Arnedo, A., Ten, J., Guerrero Villena, J., Lledó, B., Ortiz, JA, Carracedo, M.A., Llácer, J., Bernabeu. R.
  • Transf. of Embryos in Day 3 vs Day 5. MA. Carracedo, A. Rodríguez-Arnedo, J. Guerrero, MD. Pérez, J. Ten, R. Bernabeu.

 

25th Annual Meeting of the European Society of Human Reproduction & Embryology. ESHRE. Amsterdam, June, 2009.

  • Use of urofolitrophin or folitrophin-alpha in oocyte-donor women: a comparison. Rafael Bernabeu, PhD, MD, Juan Quintana-Cerezal, MD, Jorge Ten, PhD, Natalia Romera, B Sc, Jaime Guerrero, M Sc
  • Results of soft-Ivf stimulation in good prognosis patients. Rafael Bernabeu, PhD, MD, Jorge Ten, PhD, Joaquín Llácer, MD, Jaime Guerrero, M Sc
  • Comparison donor satisfaction between a GnRH antagonist and a GnRH agonist flare-up protocol: a randomized clinical trial. J. Llácer, M. Aula, N. Romera, J.M. Gomez Santana, J. Ten, R. Bernabeu, Elche/ES
  • Isolation, lysis and amplification of single sperm cells for further assays: preliminary results. G. Daina, M. Rius, A. Obradors, A. Garcia-Peiro, B. Lledo, M. Oliver-Bonet, J. Benet, J. Navarro

 

9th International Congress of Andrology. Barcelona. March 2009

  • Antioxidant treatment effect in patients with sperm DNA fragmentation and the outcome of TRA cycles. R. Morales, B. Lledó, R. Bernabeu.

 

24th Annual Meeting of the European Society of Human Reproduction & Embryology. ESHRE. Barcelona, July 2008

  • Mean Lumber of cells of embryo cohort on day two as a predictor of blastocyst formation and pregnancy. J. Ten, A. Rodríguez-Arnedo, A. Montoya, J. Llácer, R. Bernabeu.
  • Low implantation potential of delayed development embryos on day 5. J. Guerrerro Villena, J. Ten, A. Rodríguez-Arnedo, A. Montoya, R. Bernabeu.
  • Cryopreservation of oocyte and ovarian tissue. Rodríguez-Arnedo, D. as president of session 45

 

Eighth International Symposium "Preimplantation Genetic Diagnosis". Barcelona, Spain. April 2008.

  • Multiple displacement amplification in PGD: Bernabeu Institute experience
    A new approach for haplotyping in single gene PGD in couples with de novo mutations. Dra. Belén Lledó; Dra. Dori Rodríguez.
  • Morphological embryo selection: do we work correctly with recurrent miscarriage couples.
  • New approach for haplotyping single gene PGD in couples with de novo mutations.

 

 

R & D Projects

Department of Health Project, entitled "DEVELOPMENT OF A NEW TECHNIQUE FOR GENETIC DIAGNOSIS: CGH IN SINGLE CELLS" within the Research Program to Promote Health in Valencia 2011.

Department of Health Project, entitled "CREATING AN EGG AND OVARIAN TISSUE BANK" within the Research Program to Promote Health in Valencia 2011.

IMPIVA Project, entitled "GENETIC POLYMORPHISMS AND INFERTILITY" within the Development and Technological Innovation Program 2011.

IMPIVA Project, entitled "METABOLOMICS AS A NON-INVASIVE EMBRYO SELECTION" within the Development and Technological Innovation Program 2011.

IMPIVA Project, entitled "PATTERNS OF NEURONAL RECEPTOR DISTRIBUTION IN NORMAL AND ABNORMAL HUMAN SPERM", the Development and Technological Innovation Program 2011.

IMPIVA Project, entitled "EFFECT OF LOW-GROWING CONCENTRATIONS OF OXYGEN ON THE EMBRYONIC METABOLOMIC PROFILE AND CLINICAL OUTCOME IN EGG DONATION PROGRAM", the Development and Technological Innovation Program 2011.

IMPIVA Project, entitled "CORRELATION BETWEEN AMH LEVELS IN BLOOD AND FOLLICULAR FLUID AND EGG AND EMBRYO QUALITY" within the Development and Technological Innovation Program 2010.

IMPIVA Project, entitled "EFFECT OF MEDIUM VITRIFICATION USED IN CRYOPRESERVATION CYCLES OF HUMAN EMBRYOS" within the Development and Technological Innovation Program 2010.

IMPIVA Project, entitled "ASSISTED HATCHING IN VITRIFIED EMBRYOS" within the Development and Technological Innovation Program 2010.

IMPIVA Project, "STUDY OF THE DEGREE OF IMPACT OF SPERMATIC DNA FRAGMENTATION ON IVF RESULTS ", Programa de Desarrollo e Innovación Tecnológica 2009.

IMPIVA Project, "IDENTIFICATION OF BIOMARKERS OF SPERMATIC CHARACTERISTICS IN IVF ", Programa de Desarrollo e Innovación Tecnológica 2009.

IMPIVA Project, "DETERMINING THE GENTIC PROFILE OF UNDOCUMENTED EMBRYOS ", Programa de Desarrollo e Innovación Tecnológica 2009.

IMPIVA Project, "EMBRYO TRANSFER ON DAY 3 VS DAY 5 ", Programa de Desarrollo e Innovación Tecnológica 2009.

IMPIVA Project, "CREATION OF THE BIOTECHNOLOGY COMPANY, IB BIOTECH ", Programa de Desarrollo e Innovación Tecnológica 2009.

IMPIVA Project, "IMPLEMENTATION OF COMPUTERISED CLINICAL HISTORY ", Programa de Desarrollo e Innovación Tecnológica 2009.

IMPIVA Project, titled "Molecular detection of chromosome Y microdelection and their implications in the masculine infertility", within the Development and Technologycal innovation Program 2005.

PROFIT Project, titled "The sHLA-G determination in an embryonary culture as a viability marker in an IVF program", within the Promotion to the Technical Investigation Program 2006. Cience and Technology Department.

FEDER Project, titled "Antioxidants and Fertility", in colaboration with the Pharmacology and Therapeutics Department of the Miguel Hernández University in San Juan (Alicante). Project approved in November 1999.

IMPIVA Project, titled "Oocyte quality analisys and pro-nuclear morphology", within the Technological Development Program 2002.

IMPIVA Project, titled "Early antenatal diagnosis of Down Syndrome by non-invasive techniques", within the Development and Technological Innovation Program 2003.

IMPIVA Project, titled "Design of the detection of the Retinoschisis in an embryonary level", within the Promotion of the Technical Investigation program 2003.

PROFIT Project, titled "Exposure to environmental toxics and the affectation to the seminal quality", within the Development and Technological Innovation Program 2004.

IMPIVA Project, "Exposure to enviromental toxic substances and the affectation to the seminal quality".

FUNDACIÓN SÉNECA Project, titled "Morphologycal assesment of the oocyte affected by endometrioses", within the Development and Technological Investigation Program 2004.

IMPIVA Project, titled "Molecular detection of microdelections of the Y chromosome and the implications in the masculine fertility", within the Development and Technological Innovation Program 2005.

IMPIVA Project, titled "The sHLA-G determination in an embryonary culture as a viability marker in an IVF program", within the Promotion to the Technical Investigation Program 2006. Cience and Technology Department.

PROFIT Project, titled "ANALISYS OF THE PLACENTA VASCULARIZATION THROUGH TRIDIMENSIONAL POWER DOPPLER IN PREGNANT WOMEN WITH OOCYTE DONATION", within the Development and Technological Innovation Program 2007.

IMPIVA Project, titled "G-FERT VS G-1.3 TRAS ICSI: PROSPECTIVE AND RANDOMIZE ANALISYS", within the Development and Technological Innovation Program 2007.

IMPIVA Project, titled "DEVELOPMENT OF NON-INVASIVE ANTENATAL GENETIC DIAGNOSIS METHODS: PURIFICATION AND ISOLATION FOETAL CELLS IN ENDOCERVICAL SAMPLES", within the Development and Technological Innovation Program 2007.

IMPIVA Project, titled "INCONTINENTIA PIGMENTI", within Expande Program 2007.

IMPIVA Project, titled "CONFOCAL MICROSCOPIA IN CRYOPRESERVE OOCYTES",within the Development and Technological Innovation Program 2008.

IMPIVA Project, titled "NEW STRATEGIES FOR THE FAMILY STUDY OF GENETIC ILLNESSES OF NOVO: GENOMA EXTENSION", within the Development and Technological Innovation Program 2008.

IMPIVA Project, titled "DEVELOPMENT OF A NEW NON-INVASIVE METHOD FOR THE ANTENAL DIAGNOSIS", within the Development and Technological Innovation Program 2008.


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