Why don’t we do IMSI?

There is no scientific evidence to demonstrate that its use is beneficial and so its use only adds further unjustified expense to the cost of treatment. We recently evaluated the possibility of applying this technique, but recent studies have shown no clinical benefit using IMSI for the selection of sperm compared with traditional optical microscopy. Furthermore, similar rates of fertilization and of optimal quality embryos were detected between ICSI microinjected eggs and those created using spermatozoids selected using the IMSI technique. Therefore the introduction of this technique into our clinical practice has not been regarded as sufficiently justified.

Bibliography:

1.Comparison of day 2 embryo quality after conventional ICSI versus intracytoplasmic morphologically selected sperm injection (IMSI) using sibling oocytes.
Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):42-6.

2.Impact of intracytoplasmic morphologically selected sperm injection on assisted reproduction outcome: a review.
Reprod Biomed Online. 2009;19 Suppl 3:45-55. Review.

3.Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?
Fertil Steril. 2010 Mar 1;93(4):1347.e1-5.

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